Expression profiling of clonal lymphocyte cell cultures from Rett syndrome patients

Delgado, Ivan J; Kim, Dong Sun; Thatcher, Karen N; LaSalle, Janine M; Van den Veyver, Ignatia B

doi:10.1186/1471-2350-7-61

BMC Medical Genetics

Table 2 Genes with higher expression in mutant samples on microarray analysis. This table contains a list of genes with higher expression in mutant T-lymphocyte clones by one-way ANOVA analysis (p < 0.05). * indicates >1.5-fold change in expression level and ** indicates >2-fold change in expression level.

From: Expression profiling of clonal lymphocyte cell cultures from Rett syndrome patients

No.	Gene Name	P-value	Common name	Genbank No.	Description
1	219759_at	6.66E-11	LRAP	NM_022350	leukocyte-derived arginine aminopeptidase
2	206148_at	0.000152	IL3RA	NM_002183	interleukin 3 receptor, alpha (low affinity)
3*	213655_at	0.000209	YWHAE	AA502643	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein
4*	212952_at	0.000278	MNT	AA910371	calreticulin
5	218340_s_at	0.000346	FLJ10808	NM_018227	hypothetical protein FLJ10808
6*	200765_x_at	0.000507	CTNNA1	NM_001903	catenin (cadherin-associated protein), alpha 1, 102 kDa
7*	210732_s_at	0.000704	LGALS8	AF342816	lectin, galactoside-binding, soluble, 8 (galectin 8)
8	219974_x_at	0.00131	ECHDC1	NM_018479	enoyl Coenzyme A hydratase domain containing 1
9	202732_at	0.00142	PKIG	NM_007066	protein kinase (cAMP-dependent, catalytic) inhibitor γ
10	204418_x_at	0.00183	GSTM4	NM_000848	glutathione S-transferase M2 (muscle)
11	221754_s_at	0.00187	CORO1B	AI341234	coronin, actin binding protein, 1B
12*	219648_at	0.00266	FLJ10116	NM_018000	hypothetical protein FLJ10116
13*	212099_at	0.00528	RHOB	AI263909	ras homolog gene family, member B
14	213135_at	0.00579	TIAM1	U90902	T-cell lymphoma invasion and metastasis 1
15**	210844_x_at	0.00603	CTNNA1	D14705	catenin (cadherin-associated protein), alpha 1, 102 kDa
16	208743_s_at	0.00617	YWHAB	BC001359	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein
17*	204201_s_at	0.00621	PTPN13	NM_006264	protein tyrosine phosphatase, non-receptor type 13
18*	222146_s_at	0.00628	TCF4	AK026674	transcription factor 4
19*	214130_s_at	0.00717	PDE4DIP	AI821791	phosphodiesterase 4D interacting protein (myomegalin)
20**	211893_x_at	0.00833	CD6	U66145	CD6 antigen
21**	210136_at	0.00975	MBP	AW070431	myelin basic protein
22**	209012_at	0.0106	TRIO	AV718192	triple functional domain (PTPRF interacting)
23	222173_s_at	0.0109	TBC1D2	AK026105	TBC1 domain family, member 2
24	218435_at	0.0112	DNAJD1	NM_013238	DnaJ (Hsp40) homolog, subfamily D, member 1
25	210354_at	0.0122	IFNG	M29383	Human mRNA for HuIFN-gamma interferon.
26	217744_s_at	0.0132	PERP	NM_022121	PERP, TP53 apoptosis effector
27*	213822_s_at	0.0133	UBE3B	BE856776	ubiquitin protein ligase E3B
28	204412_s_at	0.015	NEFH	NM_021076	neurofilament, heavy polypeptide 200 kDa
29	200862_at	0.0151	DHCR24	NM_014762	24-dehydrocholesterol reductase
30	210949_s_at	0.0153	EIF3S8	BC000533	eukaryotic translation initiation factor 3, subunit 8, 110 kDa
31	218393_s_at	0.0172	SMU1	NM_018225	homolog of C. elegans smu-1
32	221550_at	0.018	COX15	BC002382	COX15 homolog, cytochrome c oxidase assembly protein
33*	203413_at	0.0192	NELL2	NM_006159	NEL-like 2 (chicken)
34	221036_s_at	0.0192	PSFL	NM_031301	anterior pharynx defective 1B-like
35*	210915_x_at	0.0208	PRSS1	M15564	T-cell receptor precursor
36	218943_s_at	0.0212	DDX58	NM_014314	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide
37	207813_s_at	0.0215	FDXR	NM_004110	ferredoxin reductase
38	221021_s_at	0.0216	CTNNBL1	NM_030877	catenin, beta like 1
39	214316_x_at	0.0216	MNT	AI378706	Calreticulin
40**	209728_at	0.022	HLA-DRB4	BC005312	major histocompatibility complex, class II, DR beta 3
41	215230_x_at	0.0229	EIF3S8	AA679705	eukaryotic translation initiation factor 3, subunit 8, 110 kDa
42	219269_at	0.024	FLJ21616	NM_024567	hypothetical protein FLJ21616
43**	207533_at	0.0246	CCL1	NM_002981	chemokine (C-C motif) ligand 1
44	207275_s_at	0.0255	ACSL1	NM_001995	acyl-CoA synthetase long-chain family member 1
45	217856_at	0.0274	RBM8A	AF182415	RNA binding motif protein 8A
46	200647_x_at	0.0277	EIF3S8	NM_003752	eukaryotic translation initiation factor 3, subunit 8, 110 kDa
47*	214395_x_at	0.028	PP3856	AI335509	eukaryotic translation elongation factor 1 delta
48**	211900_x_at	0.0297	CD6	U66146	CD6 antigen
49	215606_s_at	0.0307	ELKS	AB029004	Rab6-interacting protein 2
50	218945_at	0.0311	MGC2654	NM_024109	hypothetical protein MGC2654
51	209790_s_at	0.0314	CASP6	BC000305	caspase 6, apoptosis-related cysteine protease
52	201143_s_at	0.0325	EIF2S1	BC002513	eukaryotic translation initiation factor 2, subunit 1 alpha, 35 kDa
53	211965_at	0.0332	ZFP36L1	BE620915	zinc finger protein 36, C3H type-like 1
54**	201242_s_at	0.0339	ATP1B1	BC000006	ATPase, Na+/K+ transporting, beta 1 polypeptide
55	213388_at	0.0346	PDE4DIP	H15535	ym27c01.s1 Soares infant brain 1NIB cDNA clone IMAGE:49385 3'
56	214182_at	0.036	ARF6	AA243143	ADP-ribosylation factor 6
57	212190_at	0.0362	SERPINE2	AL541302	AL541302 Homo sapiens PLACENTA cDNA clone CS0DE006YI10 5'
58*	204015_s_at	0.0365	DUSP4	BC002671	dual specificity phosphatase 4
59**	206366_x_at	0.0372	XCL1	U23772	chemokine (C motif) ligand 1
60*	216609_at	0.0374	TXN	AF065241	Thioredoxin
61	219836_at	0.038	ZBED2	NM_024508	zinc finger, BED domain containing 2
62**	208602_x_at	0.0383	CD6	NM_006725	CD6 antigen
63**	208302_at	0.0385	HB-1	NM_021182	minor histocompatibility antigen HB-1
64	209433_s_at	0.0393	PPAT	AI457120	phosphoribosyl pyrophosphate amidotransferase
65**	221618_s_at	0.0404	TAF9L	AF220509	TAF9-like RNA polymerase II
66	202807_s_at	0.0427	TOM1	NM_005488	target of myb1 (chicken)
67	222145_at	0.043		AK027225	Similar to PI-3-kinase-related kinase SMG-1 isoform 1; (LOC390682)
68**	212599_at	0.0435	AUTS2	AK025298	autism susceptibility candidate 2
69	209392_at	0.0447	ENPP2	L35594	ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin)
70	204137_at	0.0453	TM7SF1	NM_003272	transmembrane 7 superfamily member 1 (upregulated in kidney)
71	209015_s_at	0.0455	DNAJB6	BC002446	DnaJ (Hsp40) homolog, subfamily B, member 6
72	209013_x_at	0.0482	TRIO	AF091395	triple functional domain (PTPRF interacting)
73	215920_s_at	0.0488	LOC283970	AC002544
74	221069_s_at	0.0492	LOC51204	NM_016360	clone HQ0477 PRO0477p
75	214741_at	0.0494	ZNF131	AW968301	zinc finger protein 131 (clone pHZ-10)
76	207485_x_at	0.0495	BTN3A1	NM_007048	butyrophilin, subfamily 3, member A1
77	220937_s_at	0.0496	SIAT7D	NM_014403	sialyltransferase 7D

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ISSN: 1471-2350

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