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Table 2 NAT2 genotypes in controls and lung cancer patients

From: N-acetyltransferase 2 (NAT2) gene polymorphisms in colon and lung cancer patients

Genotypes Deduced phenotypes Controls Lung cancer Total Odds ratios (95% confidence interval)2
c.481 C>T c.590 G>A c.857 G>A   n = 243 n = 67 n = 310  
CC GG GG rapid 5.3% (13) 7.5% (5) 5.8% (18) reference
CT    rapid 23.0% (56) 13.4% (9) 21.0% (65) 0.42 (0.12–1.46)
  GA   rapid 8.6% (21) 20.9% (14) 11.3% (35) 1.73 (0.50–5.95)
   GA rapid 0.4% (1) 0 0.3% (1)  
TT    slow1 22.2% (54) 13.4% (9) 20.3% (63) 0.43 (0.12–1.51)
  AA   slow 9.5% (23) 0 7.4% (23)  
   AA slow 0 0 0  
  AA GA slow 4.1% (10) 0 3.2% (10)  
CT GA   slow 23.9% (58) 38.8% (26) 27.1% (84) 1.17 (0.38–3.60)
CT   GA slow 2.5% (6) 4.5% (3) 2.8% (9) 1.30 (0.23–7.31)
  GA GA slow 0.4% (1) 1.4% (1) 0.6% (2) 2.60 (0.14–50.04)
  1. 1c.481C>T is a silent mutation associated also with NAT*12C (c.481C>T+ c.803A>G) which is a rapid allele (see Hein et al. 2000, [1])
  2. 2 For the calculation of ORs for individual genotypes, NAT2*4/*4 [c. 481CC + c.590 GG + c.857 GG] was used as reference and all corresponding odds ratios were determined with respect to this reference.