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Table 3 Quantitative traits of EFS parents (n = 1177), stratified by F352V genotype.

From: The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians

 

FF (95% CI)

FV (95% CI)

VV (95% CI)

P

Age (years)

31.9 (31.5–32.2)

32.1 (31.5–32.8)

31.3 (29.5–33.2)

0.68

BMI (kg/m2)

25.0 (24.7–25.2)

24.9 (24.4–25.4)

24.9 (23.7–26.3)

0.96

Fasting insulin (pmol/l)

58.2 (56.1–60.3)

60.0 (56.5–63.8)

59.3 (49.7–70.8)

0.68

Fasting glucose (mmol/l)

4.51 (4.48–4.53)

4.52 (4.48–4.56)

4.52 (4.39–4.66)

0.88

HOMA %S

81.7 (78.7–84.5)

78.0 (73.3–82.8)

79.3 (66.5–94.4)

0.43

Fasting triglycerides (mmol/l)

1.61 (1.56–1.66)

1.67 (1.58–1.75)

1.81 (1.56–2.10)

0.19

LDL-cholesterol (mmol/l)

3.21 (3.14–3.28)

3.22 (3.11–3.34)

3.18 (2.88–3.52)

0.96

HDL-cholesterol (mmol/l)

1.63 (1.61–1.66)

1.64 (1.60–1.69)

1.56 (1.44–1.69)

0.45

HDL-cholesterol (mmol/l)*

1.64 (1.61–1.66)

1.56 (1.44–1.69)

0.23

  1. Data are given as mean (95% confidence interval). For traits other than age, results are corrected for sex. For the serum fasting glucose analysis, only values < 6.0 mmol/l were included. All variables apart from age were log-transformed before analysis.
  2. *Recessive model. CI, confidence interval; BMI, body mass index; HOMA %S, Homeostasis Model Assessment of Insulin Sensitivity.