The functional

BMC Medical Genetics

Table 1 Clinical characteristics of subjects in study.

	Case Subjects	Control Subjects	Warren 2 Trios and Duos Probands
n	1793	1619	509
Male (%)	58.8	49.4	58.0
Age (years)*	51 (44–58)	32 (29–35)	41 (36–47)
BMI (kg/m²)	30.1 (26.9–34.3)	24.8 (22.1–27.9)	32.3 (28.4–37.2)
Treatment (% D/O/I)	11/62/27	-	18/63/19

Continuous data are given as median (interquartile range). Only successfully genotyped subjects are included.
BMI, body mass index; D/O/I, diet/oral hypoglycaemic agents/insulin. No clinical characteristics were available for the ECACC population control subjects, so control age and BMI are for the Exeter Family Study subjects only.
*Age at diagnosis for case subjects; age at study for control subjects.

ISSN: 1471-2350