Table 4 Genes over-expressed in +21 fetal hearts (ANOVA p < .01). Genes mapping to chromosome 21 are in bold.
Affy ID | Gene Name | Genbank | Chromosome | Description | Fold change |
|---|---|---|---|---|---|
33455_at | ALDOB | X02747 | 9q21.3-q22.2 | Aldolase B | 4.56 |
32027_at | PDZK1 | AF012281 | 1q21 | PDZ domain containing 1 | 3.99 |
39151_at | PAPPA2 | AL031290 | 1q23-q25 | Pregnancy-associated plasma protein | 3.47 |
425_at | ISG12 IFI27 | X67325 | 14q32 | Interferon, alpha-inducible protein 27 | 3.47 |
38384_at | GART | X54199 | 21q22.11 | Trifunctional metabolic enzyme (see text) | 3.02 |
35692_at | RIS1 | AL080235 | 3p21.3 | Ras-induced senescence 1 | 2.63 |
37202_at | F2 | J00307 | 11p11-q12 | Prothrombin | 2.15 |
36256_at | LSAMP | U41901 | 3q13.2-q21 | Limbic system-associated membrane protein | 2.10 |
36245_at | HTR2B | X77307 | 2q36.3-q37.1 | 5-hydroxytryptamine (serotonin) receptor 2B | 2.05 |
34316_at | RPS15A | W52024 | 16p | Ribosomal protein S15a | 1.96 |
37871_at | IAPP AMYLIN | X68830 | 12p12.3-p12.1 | Islet amyloid polypeptide (IAPP). | 1.94 |
38201_at | ECA39 | U21551 | 12pter-q12 | Branched chain aminotransferase 1, cytosolic | 1.88 |
33203_s_at | FREAC-4 | U59831 | 5q12-q13 | Forkhead related activator 4 (FREAC-4) | 1.87 |
39248_at | AQP3 | N74607 | 9p13 | Aquaporin 3 | 1.82 |
37399_at | AKR1C3 | D17793 | 10p15-p14 | 3-alpha hydroxysteroid dehydrogenase, type II | 1.81 |
32486_at | CKMM | AC005781 | 19q13.2-q13.3 | Creatine kinase, muscle | 1.81 |
1574_s_at | IL4 | M13982 | 5q31.1 | Interleukin 4 | 1.72 |
39674_r_at | ECM2 | AB011792 | 9q22.3 | Extracellular matrix protein 2 | 1.72 |
38738_at | SUMO3 | X99584 | 21q22.3 | SMT3 suppressor of mif two, homolog 3 | 1.66 |
36155_at | SPOCK2 | D87465 | 10pter-q25.3 | Sparc/osteonectin, proteoglycan (testican) 2 | 1.63 |
31623_f_at | MT1A | K01383 | 16q13 | metallothionein-I-A | 1.61 |
32250_at | CFH | X07523 | 1q32 | Complement factor H | 1.61 |
40587_s_at | EEF1E1 | AF054186 | 6p24.3-p25.1 | Eukaryotic elongation factor 1 epsilon 1 | 1.60 |
36107_at | ATP5J | AA845575 | 21q21.1 | ATP synthase, H+ transporting, mitochondrial | 1.55 |
201_s_at | B2M | S82297 | 15q21-q22.2 | Beta-2-microglobulin | 1.54 |
39767_at | CCT8 | D13627 | 21q22.11 | Chaperonin containing TCP1, subunit 8 (theta) | 1.53 |
37177_at | CD58 | Y00636 | 1p13 | CD58 antigen, (LFA-3) | 1.52 |
33358_at | PPM1H | W29087 | 12q14.1-q14.2 | Protein phosphatase | 1.52 |
36039_s_at | SH3BGR | X93498 | 21q22.3 | SH3 domain binding glutamic acid-rich protein | 1.51 |
34995_at | CALCRL | L76380 | 2q32.1 | Calcitonin receptor-like | 1.46 |
37231_at | DLG7 | D13633 | 14q22.3 | Discs, large homolog 7 (Drosophila) | 1.44 |
39005_s_at | ZNF294 | AB018257 | 21q22.11 | Zinc finger protein 294 | 1.43 |
879_at | MX2 | M30818 | 21q22.3 | Myxovirus (influenza virus) resistance 2 | 1.40 |
38066_at | NQO1 | M81600 | 16q22.1 | NAD(P)H:quinone oxireductase | 1.40 |
34667_at | NFX1 | U15306 | 9p13.3 | Nuclear transcription factor, X-box binding 1 | 1.40 |
33834_at | CXCL12 | L36033 | 10q11.1 | Chemokine (stromal cell-derived factor 1) | 1.39 |
37264_at | ZNF131 | U09410 | 5p12-p11 | Zinc finger protein 131 | 1.35 |