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Table 1 Family history of cancer in 3398delAAAAG BRCA2 mutation carriers

From: Haplotype analysis suggest common founders in carriers of the recurrent BRCA2mutation, 3398delAAAAG, in French Canadian hereditary breast and/ovarian cancer families

Family Number

Cancer site(s) and age of diagnosis of index case

Family history of breast and ovarian cancers and age at diagnosis of affected relatives

Family history of cancer at atypical sites and age at diagnosis of affected relatives

636

Br48

Br69;Ov69(M), Br30(MA)

CLL46(B), Thy;Lu50(MU), PSU50(MU), Pan44(MC)

762

Ov48;Ut48

BilBr55-57(S), Br65(PA), Br62(PC), Br45(PC), Br40(PC)

Lar60(PC), Hod/Lym55(PC), BD46(PC)

859

Br27

Br37(S), Br50(PA)

Pro55(PU), PSU63(PU)

937

Br33

Br47(S), Br44(PC), Br45(PC), Br39(PC), Br53(PC)

PSU61(F), Lu50(S),

1429

Br54

Br40;Bone46(S), Br44(MA), Br50(MA), Br52(MGM)

Pan66(M), PSU44(N), Co59(MU), Co(MU)

1430

Ov68;Pel72

Br67(S),

Leu76(S)

1441

Br52

Br49(MA), Br69(MA), Br68(MA), Ov50(MA), Br50(MA), Br58(MGM)

Lu64(MU), Brn41(MC)

1448

Ov76

Ov71(S), Br50(S), Br46(N)

 

1450

Br45;Lu80

Br35(N)

Cx25(GD), Bone;Leu14(N), PSU47(N)

1454

Br26;Co44

Br45(PA), Br52(MA), Br34(MC)

Pro54(F), Mouth80(M), Lu62(PU), Pro73(PU), St58(PGF)

1458

Br45;FT45

Br52(S), Br52(PC), Br55(MC), Br53(MC)

Pro74(PU), Co43(PC), Co54(PC), Co54(PC), PSU60(PGF), Co40(MC), Cx43(MC)

  1. Cancer site or type followed by age of diagnosis (if known): Breast (Br), bilateral breast (BilBr), ovarian (Ov), Uterus (Ut), prostate (Pro), colon (Co), chronic lymphoid leukemia (CLL), Leukemia (Leu), Lung (Lu), Pancreas (Pan), Brain (Brn), Larynx (Lar), Hodgkin's lymphoma (Hod/Lym), Bile duct (BD), Pelvic (Pel), Intestinal (In), Stomach (St), Cervix (Cx), Fallopian Tube (FT) and Primary site unknown (PSU). Affected relatives in parentheses: sister (S), brother (B), mother (M), father (F), daughter (D), granddaughter (GD), paternal aunt (PA), paternal uncle (PU), paternal cousin (PC), maternal aunt (MA), maternal uncle (MU), maternal cousin (MC), maternal grandmother (MGM), paternal grandfather (PGF) and niece (N). Multiple cancers in an individual are denoted by semicolon.