Effect of Native American ancestry on iron-related phenotypes of Alabama hemochromatosis probands with HFEC282Y homozygosity

Table 1 Characteristics of Alabama hemochromatosis probands with HFE C282Y homozygosity¹

Characteristic	Age, y	Transferrin saturation, %	Serum ferritin, ng/mL	Iron removed to achieve iron depletion, mg	Excess iron removed by phlebotomy, mg³
Men with report of Native American ancestry (n = 10)²	46 ± 10	84 ± 15	1348 (538, 3380)	7250 ± 5082	6827 ± 4701
Men without report of Native American ancestry (n = 37)	53 ± 16	85 ± 12	992 (700, 1404)	6962 ± 6829	6484 ± 5773
Value of p	0.1532	0.8966	0.4988	0.9156	0.8917
Women with report of Native American ancestry (n = 12)²	48 ± 10	71 ± 20	465 (198, 1093)	5066 ± 5398	4660 ± 4640
Women without report of Native American ancestry (n = 21)	53 ± 13	80 ± 18	415 (288, 598)	3378 ± 3444	3271 ± 3215
Value of p	0.2948	0.2251	0.4194	0.4194	0.4402

¹Age, transferrin saturation at diagnosis, and units of phlebotomy to achieve iron depletion data are displayed as mean ± 1 standard deviation (SD). Serum ferritin concentrations at diagnosis are displayed as mean (95% confidence intervals) of antilogs of log_e-transformed measurements. Comparisons of mean variables of respective subgroups of men and women were made using univariate technique (two-tail Student t-test).
²The mean proportion of Native American ancestry (± 1 SD) estimated as previously described [22] was 24.3 ± 11.9 in men and 32.3 ± 22.9 in women (p = 0.3119).
³These data were computed using quantities of iron removed by phlebotomy to achieve iron depletion, and the assumptions described in Methods, Diagnosis of hemochromatosis and evaluation of iron overload.

ISSN: 1471-2350