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Table 3 Genotyping of rs6531 in the RXRB gene.

From: On the Wegener granulomatosis associated region on chromosome 6p21.3

Genotypes/phenotypes/alleles

Patients ANCA+ (n = 151)

Patients ANCA- (n = 36)

Controls (n = 201)

 

CC

36

15

92

 

CT

87

19

88

 

TT

28

2

21

 

CC+CT ( vs . TT)

123

34

180

 

TT+CT ( vs . CC)

115

21

109

 

C

159

49

272

 

T

143

23

130

 
 

ANCA + against ANCA - patients

ANCA + patients against controls

Genotypes/phenotypes/alleles

    
 

P value

OR (95 % C.I.)

P value

OR (95 % C.I.)

CC

0.03

 

2.3 × 10-5

 

CT

0.10

1.91 (0.87 to 4.16)*

1.6 × 10-4

2.53 (1.55 to 4.11)*

TT

0.02

5.83 (1.23 to 27.65)*

0.03

5.89 (3.01 to 11.53)*

CC+CT ( vs . TT)

0.07

0.26 (0.06 to 1.14)

0.03

0.51 (0.29 to 0.94)

TT+CT ( vs . CC)

0.03

2.26 (1.17 to 4.88)

2.3 × 10-5

2.70 (1.69 to 4.30)

C

1.0 × 10-2

 

5.2 × 10-5

 

T

 

1.91 (1.11 to 3.30)

 

1.88 (1.38 to 2.56)

  1. OR = odds ratio, C.I. = confidence interval.
  2. *Odds ratios for the CT and TT genotypes are contrasted against the CC genotype. No evidence for statistical difference between the ANCA-negative WG patients and the control cohort was revealed, when calculating all off above-used comparisons.