Figure 2

illustrates the variance between families in SBP and the familial clustering of SBP level (i.e., VPC) along individual age and in users and non-users of ACE-inhibitors. Because of the existence of slope variance (Figure 1) the familial SBP variance (Figure 2A) and the VPC (Figure 2B) became a function of age and use of ACE inhibitors. Familial clustering of SBP (i.e., VPC) seems increase with age and this effect is more evident among non users of ACE inhibitors. In users of ACE inhibitors familial clustering of SBP is already evident in younger ages. Inclusion of the ACE gene I/D polymorphism in model III (red colour) reduces the familial clustering of SBP even if this effect is small. Consider that the estimations are insecure at ends of the curves since the number of individuals is small. The information illustrated in figure 2 is also numerically presented in table 4.