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Table 2 Distribution of major haplotype blocks in LMNA among patients with premature CAD and the control population.

From: Aging syndrome genes and premature coronary artery disease

Haplotype

Frequency

Haplotype

i

ii

iii

iv

v

vi

vii

viii

ix

x

xi

Overall

PCAD*

Controls

p-value

I

C

G

G

A

T

G

C

G

A

C

G

0.44

0.43

0.45

0.55

II

C

G

G

A

T

G

T

G

A

C

G

0.30

0.29

0.29

0.85

III

T

G

G

A

T

G

C

G

A

C

A

0.13

0.13

0.14

0.82

IV

T

T

A

G

C

A

C

C

G

T

G

0.05

0.05

0.07

0.25

V

T

G

G

A

T

G

C

G

A

C

G

0.05

0.05

0.04

0.41

VI

T

G

G

G

T

A

C

C

A

T

G

0.02

0.02

0.01

0.23

  1. SNP ids; i-rs2485662;ii-rs517606;iii-rs593987;iv-rs528636;v-rs508641;vi-rs553016;vii-rs4641;viii-rs7339;ix-rs568036;x-rs568035;xi-rs6669212.
  2. *PCAD: Group with premature coronary artery disease
  3. 2 SNPs (rs3204564 and rs536857) that were not in Hardy Weinberg equilibrium were excluded.
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BMC Medical Genetics

ISSN: 1471-2350

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