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Table 5 Haplotypes for 8, 4, and 3 Markers Observed in the African American Population

From: Insulin Promoter Factor 1 variation is associated with type 2 diabetes in African Americans

Variants

No

Haplotype

Case Freq

Control Freq

ChiSq

P value

Simulated p value

Global p

1,4,6,5,2,11,8,P

 
 

1

CAGCGIGD

0.531

0.511

0.326

0.5683

1

0.01

 

2

TTTCGDTD

0.103

0.145

3.336

0.0678

0.465

 
 

3

CTGCAIGD

0.112

0.124

0.247

0.6193

1

 
 

4

CAGCGIGI

0.108

0.064

4.676

0.0306

0.239

 
 

5

CAGTGIGD

0.072

0.046

2.389

0.1222

0.693

 
 

6

TTGCGDGD

0.031

0.067

5.873

0.0154

0.131

 
 

7

CTGCGIGD

0.026

0.024

0.014

0.9057

1

 

1,4,11,P

        
 

1

CAID

0.622

0.565

3.197

0.0738

0.3053

0.01

 

2

TTDD

0.138

0.209

9.084

0.0026

0.0094

 
 

3

CTID

0.143

0.151

0.134

0.714

0.9995

 
 

4

CAII

0.088

0.059

2.735

0.098

0.3809

 

1,4,11

        
 

1

CAI

0.71

0.625

7.96

0.0048

0.02

0.01

 

2

TTD

0.138

0.209

9.085

0.0026

0.011

 
 

3

CTI

0.145

0.152

0.091

0.763

1

 
  1. Haplotypes observed at over 1% frequency for all 8 variants, the 4 variants typed in additional individuals, and the three variants that showed an association with T2DM. Simulated p values are based on 10,000 simulations in HaploView 3.2; global p values are based on simulations conducted in Phase 2.1.1.