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Table 1 Biochemical characteristics of the C282Y homozygous patients before and after the implementation of the genetic test.

From: Impact of HFEgenetic testing on clinical presentation of hereditary hemochromatosis: new epidemiological data

 

Diagnosis based on HFEgenotyping

Crude p-value

Adjusted* p-value

 

No

Yes

  
 

mean

(SD)

mean

(SD)

  

   No. of patients

91

 

324

   

   Gender (no. and % of males)

72

(79.1%)

164

(50.6%)

p < 10-5

-

Males

      

   Serum ferritin (μg/L)

1886.6

(1769.7)

1136.9

(951.0)

<0.001

<0.001

   Serum iron (μmol/L)

40.7

(6.9)

36.7

(6.7)

<0.001

<0.001

   Transferrin saturation (%)

79.9

(11.9)

83.0

(13.2)

0.090

0.134

Females

      

   Serum ferritin (μg/L)

1418.0

(1457.9)

475.7

(744.6)

<0.001

<0.001

   Serum iron (μmol/L)

36.6

(8.2)

33.1

(7.4)

0.052

0.029

   Transferrin saturation (%)

77.2

(13.4)

75.9

(14.4)

0.710

0.714

  1. * Adjusted for age at diagnosis and alcohol consumption