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Table 2 Distribution of MTHFR variants in cases and controls and their association with childhood acute lymphoblastic leukemia in patients from trial ALL-BFM 2000

From: Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and susceptibility to pediatric acute lymphoblastic leukemia in a German study population

MTHFR Cases (n = 443) Number (%) Controls (n = 379) Number (%) Odds ratio (95% CI) P
677 CC/1298 AA 49 (11.1) 45 (11.9) 1.00a  
677 CT/1298 AA 101 (22.8) 67 (17.7) 1.38 (0.83–2.30) 0.21
677 TT/1298 AA 44 (9.9) 41 (10.8) 0.99 (0.55–1.77) 0.96
677 CC/1298 AC 101 (22.8) 87 (23.0) 1.07 (0.65–1.75) 0.80
677 CT/1298 AC 100 (22.6) 85 (22.4) 1.08 (0.66–1.78) 0.76
677 TT/1298 AC 3 (0.7) 2 (0.5) 1.38 (0.22–8.63) 0.73
677 CC/1298 CC 45 (10.2) 52 (13.7) 0.79 (0.45–1.40) 0.43
677 CT/1298 CC n.d.   n.d.   - -
677 TT/1298 CC n.d.   n.d.   - -
  1. n.d., not detected; CI, confidence interval; areference category