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Table 5 NAT2 phenotype distribution in AD cases and controls.

From: NAT gene polymorphisms and susceptibility to Alzheimer's disease: identification of a novel NAT1 allelic variant

NAT2 PHENOTYPE

AD CASES (N = 45)

CONTROLS (N = 63)

OR (95% CI)

fast acetylator

17 (0.38)

22 (0.35)

1.00

slow acetylator

28 (0.62)

41 (0.65)

0.88 (0.40, 1.96)

TOTAL

45 (1.00)

63 (1.00)

-

  1. The number and frequency (in brackets) of fast and slow NAT2 acetylators in 45 AD cases and 63 controls is shown. Based on their genotype, AD cases and controls were classified as either 'fast' or 'slow' NAT2 acetylators. Individuals homozygous or heterozygous for the NAT2*4 allele were assigned fast NAT2 acetylators, individuals who carried two 'slow' NAT2 alleles (NAT2*5A, NAT2*5B, NAT2*5C, NAT2*6A and NAT2*7B) in any combination were assigned slow NAT2 acetylators [31]. The OR of AD to non-disease is given with 95% CI for each NAT2 phenotype (with NAT2 fast acetylator as the reference group).
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BMC Medical Genetics

ISSN: 1471-2350

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