Candidate high myopia loci on chromosomes 18p and 12q do not play a major role in susceptibility to common myopia

BMC Medical Genetics

Table 2 Power and ELods from 100 replicates of simulated data, dominant susceptibility allele frequency of 0.01

PENETRANCE IN DD:Dd SUSC. ALLELE CARRIERS	PENETRANCE IN dd NORMAL HOMOZYGOTE	% FAMILIES LINKED
		100%		75%		50%		25%
		Power¹	ELod ± s.d.²	Power¹	ELod ± s.d.²	Power¹	ELod ± s.d.²	Power¹	ELod ± s.d.²
0.8	0.08	100	14.0 ± 0.3	99	8.9 ± 0.3	82	4.7 ± 0.2	18	1.7 ± 0.1
0.8	0.15	100	14.7 ± 0.3	100	9.1 ± 0.3	73	4.8 ± 0.2	14	1.6 ± 0.1
0.7	0.08	100	14.8 ± 0.3	99	8.5 ± 0.3	77	4.8 ± 0.2	17	1.8 ± 0.15
0.7	0.15	100	15.2 ± 0.3	99	8.8 ± 0.3	70	4.5 ± 0.2	14	1.6 ± 0.1
0.6	0.08	100	15.0 ± 0.3	98	8.6 ± 0.25	67	4.3 ± 0.2	14	1.7 ± 0.1
0.6	0.15	100	14.2 ± 0.3	100	8.4 ± 0.3	73	4.3 ± 0.2	5	1.2 ± 0.1

¹Power = 100 X Proportion of replicate samples that yielded a homogeneity LOD score ≥ 3.0 ²ELod = average homogeneity LOD score over all replicates ± its standard deviation

ISSN: 1471-2350