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Table 6 Relative bias and RMSE of the disease risks predicted using the full model in the third scenario.

From: The impact of population heterogeneity on risk estimation in genetic counseling

  

AB NE(c)

AB E(d)

BB NE

rAB,NE (a)

rAA,E (b)

Relative risk

RMSE

Relative risk

RMSE

Relative risk

RMSE

0.2

0.2

0.0030

0.0194

0.0005

0.0419

0.0086

0.0174

 

0.4

0.0096

0.0221

-0.0049

0.0431

0.0072

0.0174

 

0.6

0.0117

0.0261

-0.0133

0.0451

0.0250

0.0177

 

0.8

0.0197

0.0313

-0.0123

0.0460

0.0238

0.0165

0.6

0.2

-0.0052

0.0193

-0.0120

0.0444

0.0127

0.0166

 

0.4

0.0141

0.0231

-0.0087

0.0464

0.0171

0.0171

 

0.6

0.0179

0.0262

-0.0080

0.0460

0.0052

0.0172

 

0.8

0.0285

0.0329

-0.0075

0.0457

0.0319

0.0172

  

BB E

AA NE

AA E

rAB,NE

rAB,E

Relative risk

RMSE

Relative risk

RMSE

Relative risk

RMSE

0.2

0.2

0.0051

0.0377

-0.0013

0.0388

-0.0067

0.0698

 

0.4

-0.0076

0.0364

-0.0013

0.0401

-0.0121

0.0728

 

0.6

0.0060

0.0369

-0.0011

0.0397

-0.0144

0.0757

 

0.8

0.0171

0.0382

0.0012

0.0409

-0.0096

0.0789

0.6

0.2

0.0093

0.0385

-0.0041

0.0401

-0.0133

0.0831

 

0.4

-0.0009

0.0377

-0.0006

0.0402

-0.0166

0.0860

 

0.6

-0.0081

0.0390

0.0028

0.0403

-0.0113

0.0896

 

0.8

0.0262

0.0399

-0.0007

0.0393

-0.0098

0.0916

  1. (a) Proportion of AB individuals not exposed to the environment who get the disease with a very low probability (0.01). (b) Proportion of AB individuals exposed to the environment who get the disease with a very low probability (0.01). (c) Not exposed to the environmental factor. (d) Exposed to the environmental factor.