The impact of population heterogeneity on risk estimation in genetic counseling

BMC Medical Genetics

Table 2 Relative bias and RMSE of the disease risks predicted using the full model in the first scenario.

Contam Factor ^(a)	AB NE^(b)		AB E^(c)		BB NE
	Relative bias	RMSE	Relative bias	RMSE	Relative bias	RMSE
0	0.0002	0.01786	0.0088	0.03874	0.0053	0.0168
0.2	0.0053	0.01940	0.0094	0.04196	0.0028	0.01626
0.4	0.0078	0.02154	-0.006	0.04085	-0.0092	0.01643
0.6	0.0113	0.02564	0.0023	0.04316	0.0177	0.01692
0.8	0.0230	0.03089	0.0009	0.04522	0.0284	0.01755
Contam Factor	BB E		AA NE		AA E
	Relative bias	RMSE	Relative bias	RMSE	Relative bias	RMSE
0	0.0170	0.03801	0.0040	0.03805	0.0045	0.06422
0.2	0.0121	0.03699	-0.0042	0.03842	-0.0041	0.06724
0.4	-0.0131	0.03755	0.0001	0.03925	-0.0099	0.06803
0.6	0.0211	0.03736	0.0037	0.03895	0.0000	0.06866
0.8	0.0278	0.03892	0.0036	0.04021	-0.0021	0.06951

(a) Proportion of individuals in the contaminated category who get the disease with a very low probability (0.01). (b) Not exposed to the environmental factor. (c) Exposed to the environmental factor.

ISSN: 1471-2350