The impact of population heterogeneity on risk estimation in genetic counseling

BMC Medical Genetics

Table 1 Relative bias and RMSE of the disease risks predicted using the reduced model in the first scenario.

Contam Factor ^(a)	AB NE^(b)		AB E^(c)		BB NE
	Relative bias	RMSE	Relative bias	RMSE	Relative bias	RMSE
0	-0.0030	0.0179	0.0098	0.039	-0.0007	0.0168
0.2	-0.1481	0.022	-0.0510	0.0424	-0.0342	0.016
0.4	-0.2928	0.0326	-0.1346	0.0471	-0.0792	0.0162
0.6	-0.4346	0.0452	-0.2032	0.0567	-0.0959	0.0165
0.8	-0.5725	0.0582	-0.2980	0.0710	-0.1374	0.0173
Contam Factor	BB E		AA NE		AA E
	Relative bias	RMSE	Relative bias		Relative bias	RMSE
0	0.0157	0.0381	0.0065	0.0383	0.0087	0.0647
0.2	0.068	0.0393	-0.0173	0.039	0.0379	0.0704
0.4	0.1038	0.0421	-0.0299	0.0405	0.0730	0.0770
0.6	0.2151	0.0479	-0.0456	0.0412	0.1302	0.094
0.8	0.3071	0.0559	-0.0695	0.0452	0.1819	0.1132

(a) Proportion of individuals in the contaminated category who get the disease with a very low probability (0.01). (b) Not exposed to the environmental factor. (c) Exposed to the environmental factor.

ISSN: 1471-2350