HLA-A and -B alleles and haplotypes in 240 index patients with common variable immunodeficiency and selective IgG subclass deficiency in central Alabama

Table 7 CVID and IgGSD Index Cases Positive for Haplotype A01-B08.¹

Serum Immunoglobulin Concentrations	Total IgG Concentration, frequency in 195 Index Cases (fraction)	IgA Concentration, frequency in 195 Index Cases (fraction)	IgM Concentration, frequency in 195 Index Cases (fraction)
No Deficiency²	0.23 (23/100)	0.24 (39/162)	0.24 (41/169)
Deficiency²	0.27 (26/95)	0.30 (10/33)	0.31 (8/26)

¹ Comparisons of positivity for HLA haplotype A*01-B*08 revealed no significant differences (Chi-square analysis) in index cases grouped by serum total IgG, IgA, and IgM concentration, respectively. ² Deficiency of an immunoglobulin class was defined by a serum concentration at diagnosis that was less than the corresponding lower reference limit.

ISSN: 1471-2350