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Table 1 Frequency and disease risk of 5 classes of genotypes under the model.

From: Effect of human leukocyte antigen heterozygosity on infectious disease outcome: The need for allele-specific measures

Class

Susceptible homozygotes

Heterozygote of susceptible alleles

Heterozygote with one R and one S allele

Heterozygote of resistant alleles

Resistant homozygotes

Genotype

S i S i

S i S i , i ≠ j

R i S j

R i R j , i ≠ j

R i R i

Frequency

Θ

q 2 - Θ

2 pq

p 2 - Π

Π

Probability of Favorable Outcome

x

ax

bx

cx

dx

  1. Notation: Frequency of allele S i is q i ; frequency of allele R i is p i . p = p i ; q = q i = 1 - p; ; . The subscripts of R alleles and the subscripts of the S alleles are unrelated.