Figure 6

Schematic representation of the epistatic interaction between SNPs rs7071836 and rs257174. While promoter SNP rs7071836 regulates CD39 expression in Treg, the allelic state of rs257174 determines basal expression of FAM134B in monocytes. CD39 depletes extracellular ATP by hydrolyzing this damage-associated molecular pattern but the extent of ATP depletion depends directly on the allelic state of rs7071836. In turn, monocyte basal expression of FAM134B is regulated by rs257174 and is modulated by the concentration of ATP in the extracellular space. Host cell damage-associated ATP is thus the putative functional link that supports epistatic interaction of rs7071836 and rs257174 in determining AR risk.