Identification of a genetic variant at 2q12.1 associated with blood pressure in East-Asians by genome-wide scan including gene-environment interactions

Table 4 Effect of rs13390641 on BP by BMI sub-groups

Trait	BMI sub-group	n	Beta (se)	P
SBP	BMI < 18.5	212	-2.26 (2.18)	0.2993
	18.5 ≤ BMI < 25	6700	-0.02 (0.43)	0.9540
	25 ≤ BMI < 30	3850	-0.10 (0.58)	0.8690
	30 ≤ BMI	427	5.35 (1.81)	0.0032
DBP	BMI < 18.5	212	-2.34 (1.37)	0.0884
	18.5 ≤ BMI < 25	6700	-0.01 (0.29)	0.9600
	25 ≤ BMI < 30	3850	0.06 (0.39)	0.8720
	30 ≤ BMI	427	3.50 (1.18)	0.0032

SBP, systolic blood pressure; DBP, diastolic blood pressure; BMI, body mass index; n, sample size of each subgroup; Beta, standardized regression coefficient; se, standard error; The association analyses between BP and rs13390641 in each group were performed using linear regression adjusted by age and sex.

ISSN: 1471-2350