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Table 3 Correlations between serum SP-D levels and SFTPD gene polymorphisms

From: Differences in serum SP-D levels between German and Japanese subjects are associated with SFTPDgene polymorphisms

 

Variable

Regression coefficient (95% CI.)

pvalue

VIF

rs721917

Univariate model

   
 

C/C vs T/C vs T/T

55.276 (28.473 – 82.079)

< 0.001

 
 

Multivariate model

   
 

C/C vs T/C vs T/T

35.149 (15.341 – 54.957)

< 0.001

1.031

 

Age

-0.444 (-2.009 – 1.121)

0.578

1.978

 

Japanese vs German

24.061 (-13.125 – 61.246)

0.204

1.437

 

HS vs patients with IIPs

307.740 (260.743 – 354.736)

< 0.001

2.515

rs1998374

Univariate model

   
 

C/C vs T/C vs T/T

86.550 (59.832 – 113.269)

< 0.001

 
 

Multivariate model

   
 

C/C vs T/C vs T/T

36.172 (14.289 – 58.056)

0.001

1.203

 

Age

-0.353 (-1.918 – 1.213)

0.658

1.972

 

Japanese vs German

11.114 (-28.165 – 50.393)

0.578

1.598

 

HS vs patients with IIPs

304.645 (257.602 – 351.689)

< 0.001

2.511

rs2243639

Univariate model

   
 

C/C vs T/C vs T/T

38.179 (8.965 – 67.393)

0.011

 
 

Multivariate model

   
 

C/C vs T/C vs T/T

22.707 (1.310 – 44.104)

0.038

1.017

 

Age

-0.360 (-0.449 – 0.654)

0.654

1.976

 

Japanese vs German

29.314 (-8.000 – 66.627)

0.123

1.423

 

HS vs patients with IIPs

306.421 (259.045 – 353.798)

< 0.001

2.514

rs3088308

Univariate model

   
 

A/A vs A/T

37.750 (-37.732 – 113.231)

0.326

 
  1. The genotypes of each single nucleotide polymorphism are arranged in the order of lowest to highest serum SP-D levels.
  2. CI, Confidence interval; HS, Healthy subjects; IIPs, Idiopathic interstitial pneumonias; VIF, Variance inflation factor.