Skip to main content

Table 5 GCLC-129C > T and GCLC-3506A > G haplotype polymorphisms in modifier genes associated with categorical variables of cystic fibrosis severity

From: Polymorphisms in the glutathione pathway modulate cystic fibrosis severity: a cross-sectional study

CFTRgroup

PI taking into account

Haplotype

Genotype

Variable

pc

OR

CI (5–95%)

AX

    

Presence

Absence

Total

   

Two mutation identified

No

GCLC-129C > T + GCLC-3506A > G

CC + AA

10

26

36

 

17.9

2.781-411.6

CC + (AG or GG)

1

30

31

0.024

0.149

0.007-0.959

(CT or TT) + GG

0

13

13

 

-

-

   

TT + GG

0

5

5

 

-

-

  1. Statistical analysis was performed by χ2 test. CFTR, Cystic fibrosis transmembrane regulator; GCLC, Glutamate-cysteine ligase catalytic subunit; PI, Pancreatic insufficiency; AX, Achromobacter xylosoxidans; pc, P-value corrected by Bonferroni test; OR, Odds ratio; CI, Confidence interval.