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Table 13 GSTM1/GSTT1 deletion polymorphism in association with CF clinical variables as distributed by CFTR mutation

From: Polymorphisms in the glutathione pathway modulate cystic fibrosis severity: a cross-sectional study

Variable

Without taking CFTRmutation into account

No CFTRmutations identified

No CFTRmutations identified with PI

One identified CFTRmutation

One identified CFTRmutation with PI

Two identified CFTRmutations

p-value

p-corrected

p-value

p-corrected

p-value

p-corrected

p-value

p-corrected

p-value

p-corrected

p-value

p-corrected

Gendera

0.036

0.144

0.943

1

0.601

1

0.369

1

0.114

0.456

0.014

0.056

Agea

0.331

1

0.647

1

0.496

1

0.054

0.216

0.149

0.596

0.908

1

Onset of symptomsa

0.300

1

0.996

1

0.835

1

0.579

1

0.854

1

0.049

0.196

Onset of pulmonary diseasea

0.588

1

0.359

1

0.431

1

0.776

1

0.267

1

0.559

1

Onset of digestive diseasea

0.626

1

0.480

1

0.581

1

0.433

1

0.458

1

0.051

0.204

Diagnosisa

0.520

1

0.207

0.828

0.490

1

0.710

1

0.510

1

0.992

1

BMIa

0.283

1

0.954

1

0.717

1

0.252

1

0.998

1

0.596

1

Bhalla scoreb

0.088

0.352

0.005

0.02

0.915

1

0.381

1

0.218

0.872

0.481

1

Kanga scoreb

0.885

1

0.443

1

0.216

0.864

0.912

1

0.261

1

0.455

1

Shwachman-Kulczycki scoreb

0.627

1

0.144

0.576

0.087

0.348

0.387

1

0.104

0.416

0.195

0.780

Nasal polyposisa

0.098

0.392

0.483

1

0.699

1

0.467

1

0.362

1

0.102

0.408

Diabetes mellitusa

0.259

1

0.240

0.96

0.790

1

0.992

1

0.555

1

0.334

1

Osteoporosisa

0.204

0.816

0.501

1

0.525

1

0.427

1

0.187

0.748

0.386

1

Meconium ileus

0.683

1

0.266

1

0.348

1

0.517

1

0.905

1

0.626

1

Pancreatic insufficiencya

0.965

1

0.791

1

-

-

0.975

1

-

-

0.653

1

SpO2b

0.449

1

0.021

0.084

0.557

1

0.616

1

0.774

1

0.786

1

FVC(%)b

0.576

1

0.518

1

0.859

1

0.928

1

0.475

1

0.758

1

FEV1(%)b

0.778

1

0.182

0.728

0.977

1

0.799

1

0.827

1

0.657

1

FEV1/FVCb

0.178

1

0.007

0.028

0.265

1

0.789

1

0.395

1

0.593

1

FEF25–75%b

0.881

1

0.014

0.056

0.751

1

0.719

1

0.370

1

0.382

1

First P. aeruginosa a

0.545

1

0.686

1

0.295

1

0.019

0.076

0.299

1

0.123

0.492

P. aeruginosa mucoida

0.134

0.536

0.118

0.472

0.492

1

0.575

1

0.940

1

0.337

1

P. aeruginosa no mucoida

0.487

1

0.051

0.204

0.682

1

0.167

0.668

0.190

0.760

0.847

1

A. xylosoxidans a

0.541

1

0.779

1

0.663

1

0.079

1

0.537

1

0.995

1

S. aureus a

0.660

1

0.243

0.972

0.839

1

0.716

1

0.181

0.724

0.667

1

B. cepacia a

0.861

1

0.142

0.568

0.054

1

0.759

1

0.145

0.580

0.640

1

  1. aFisher’s exact test used for categorical variables; bStudent’s t-test used for numerical variables. P-values < 0.05 denote clinical association (bold).
  2. CFTR, Cystic fibrosis transmembrane regulator; GSTM1, Glutathione S-transferase mu 1; GSTT1, Glutathione S-transferase theta 1; PI, Pancreatic insufficiency; BMI, Body mass index; SpO2, Hemoglobin oxygen saturation in the blood; FVC, Forced vital capacity; FEV1, Forced expiratory volume in the first second; FEF, Forced expiratory flow between 25 and 75% of vital capacity.