Genetic and functional evidence for a locus controlling otitis media at chromosome 10q26.3

BMC Medical Genetics

Table 1 Results of multi-point and single-point non-parametric linkage analysis in the WAFSOM across chromosomal regions previously[6, 7] linked to OM

Marker name	Genetic map location (cM) Marshfield	Physical location (Start; Mb) NCBI build 36	Single-point Z_lr	P value	Multi-point Z_lr	P value	Information content
*Chromosome 3p25.3*
D3S1304	22	6.89	0.00	0.500	−0.93	0.175	0.88
D3S3691	29	8.82	−0.24	0.405	−1.15	0.126	0.90
D3S1597	30	9.34	−0.76	0.225	−1.04	0.149	0.92
D3S1263	36	11.49	−0.22	0.412	−1.13	0.130	0.88
D3S1259^a	37	12.07	−0.14	0.444	−0.87	0.192	0.76
*Chromosome 10q22.3*
D10S1730	99	78.60	1.56	0.060	1.48	0.070	0.87
D10S206	98	79.45	1.88	0.031	1.65	0.050	0.83
D10S1677	100	79.88	0.30	0.383	1.40	0.081	0.87
D10S201	102	80.69	1.71	0.044	1.46	0.072	0.86
*Chromosome 10q26.3*
D10S1655	162	130.85	1.52	0.065	1.65	0.050	0.85
D10S169	173	132.41	1.30	0.098	2.51	0.006	0.91
D10S1770	169	132.57	2.27	0.012	2.69	0.004	0.92
D10S212^a	171	134.29	1.66	0.048	2.42	0.008	0.87
D10S1711	171	135.05	0.90	0.183	2.52	0.006	0.85
*Chromosome 17q12*
D17S1293	56	29.58	0.32	0.373	0.40	0.345	0.87
D17S933	58	30.22	0.36	0.361	0.28	0.391	0.84
D17S927	58	32.08	0.68	0.247	0.46	0.324	0.88
D17S946	60	34.11	1.63	0.052	1.09	0.137	0.84
*Chromosome 19q13.43*
D19S572	89	58.80	−0.23	0.409	−0.22	0.413	0.81
D19S210	100	61.71	0.01	0.500	−0.85	0.198	0.94
D19S887	100	62.33	−0.60	0.274	−0.13	0.447	0.96
D19S254	101	62.36	0.19	0.425	−0.22	0.414	0.95
D19S214^a	101	62.47	−1.85	0.032	−0.44	0.330	0.95

ISSN: 1471-2350