Skip to main content

Table 2 Associations of common variants with type 2 diabetes in urban Ghana

From: The TCF7L2 rs7903146 (T) allele is associated with type 2 diabetes in urban Ghana: a hospital-based case–control study

Gene SNP

Genotype

N

Controls

Type 2 diabetes

OR (9% CI)

P

aOR (95% CI)a

P

TCF7L2 rs7903146

n

1049

375

674

    
 

C/C

455

182 (48.5)

273 (40.5)

Reference

   
 

C/T

488

165 (44.0)

323 (47.9)

    
 

T/T

106

28 (7.5)

78 (11.6)

1.34 (1.10–1.63)

0.004

1.39 (1.07–1.81)

0.014

 

MAF (T)

 

0.30

0.36

    

KCNJ11 rs5219

n

1052

377

675

    
 

A/A

1051

377 (100)

674 (99.9)

Reference

   
 

A/G

1

0 (0)

1 (0.1)

    
 

G/G

0

0 (0)

0 (0)

-

 

-

 
 

MAF (G)

 

0.0

0.0007

    

PPARγ rs1801282

n

1021

365

656

    
 

C/C

1020

365 (100)

655 (99.8)

Reference

   
 

C/G

1

0 (0)

1 (0.2)

    
 

G/G

0

0 (0)

0 (0)

-

 

-

 
 

MAF (G)

 

0.0

0.0008

    

CAPN10 rs3792267

n

1048

375

673

    
 

G/G

826

289 (77.1)

537 (79.8)

Reference

   
 

G/A

209

80 (21.3)

129 (19.2)

    
 

A/A

13

6 (1.6)

7 (1.0)

0.85 (0.64–1.12)

0.25

0.70 (0.47–1.03)

0.07

 

MAF (A)

 

0.13

0.11

    

CAPN10 rs3842570

n

1048

374

674

    
 

2 repeats/2 repeats

622

225 (60.2)

397 (58.9)

Reference

   
 

2 repeats/3 repeats

376

128 (34.2)

248 (36.8)

    
 

3 repeats/3 repeats

50

21 (5.6)

29 (4.3)

1.00 (0.80–1.24)

0.99

1.12 (0.84–1.49)

0.45

 

MAF (3 repeats)

 

0.23

0.23

    

CAPN10 rs5030952

n

1048

374

674

    
 

C/C

219

79 (21.1)

140 (20.8)

Reference

   
 

C/T

523

182 (48.7)

341 (50.6)

    
 

T/T

306

113 (30.2)

193 (28.6)

0.98 (0.81–1.17)

0.79

0.98 (0.76–1.25)

0.84

 

MAF (T)

 

0.55

0.54

    
  1. MAF, minor allele frequency. a, The multivariate odds ratio is adjusted for age, gender, BMI ≥25.0 kg/m2 and hypertension status.