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Table 3 Association of the APOAI rs670 (g.-75G > A) and the rs5069 (g. + 83C > T) polymorphisms and lipid profiles

From: Re-sequencing of the APOAI promoter region and the genetic association of the -75G > A polymorphism with increased cholesterol and low density lipoprotein levels among a sample of the Kuwaiti population

SNP

 

W/W

 

W/M

 

M/M

p

 

n

 

n

 

n

  

SNPs relation with LDL

       

rs670

344

2.99 ± 0.04

164

3.17 ± 0.06

21

3.03 ± 0.14

0.02

rs5069

491

3.07 ± 0.03

37

3.02 ± 0.14

1

3.00

0.59

SNPs relation with TC

       

rs670

358

4.58 ± 0.04

170

4.75 ± 0.07

21

4.64 ± 0.19

0.03

rs5069

511

4.64 ± 0.04

37

4.60 ± 0.16

1

5.12

0.78

SNP relation with HDL

       

rs670

344

1.18 ± 0.01

164

1.15 ± 0.02

21

1.28 ± 0.1

0.22

rs5069

491

1.18 ± 0.01

37

1.15 ± 0.04

1

1.02

0.79

SNP relation with TG

       

rs670

358

0.74

170

0.72

21

0.68

0.93

  

(0.49–1.21)

 

(0.48–1.14)

 

(0.40–0.95)

 

rs5069

511

0.72

37

0.78

1

2.35

0.83

  

(0.48–1.18

 

(0.53–1.15)

   
  1. W/W, homozygous for common allele; W/M heterozygous for minor allele; M/M, homozygous for minor allele. The lipid level values are represented as mmol/L. Data shown as means ± SEM or for the lipid levels except for TG where the median and inter-quartile range is represented. p values were derived from multiple linear regressions with adjustment for sex, BMI and age assuming an additive genetic model. Significant values (p < 0.05) are shown in bold.