Sequence variants in oxytocin pathway genes and preterm birth: a candidate gene association study

BMC Medical Genetics

Table 6 Results of regression analyses of OXTR coding variants detected in Iowa case and control mothers

(A) Model¹	n(case, control)	P		R2
rs4686302 (A218T)	60, 60	0.19		0.020
rs237902 (N230N)	60, 60	0.24		0.015
rs61740241 (A238T)	60, 59	0.75		0.001
rs4686302 (A218T) + rs237902 (N230N)²	60, 60	0.04, 0.05³		0.062
(B) Model ¹	n	Gestational age		Birth weight
(B) Model ¹	n	P	R2	P	R2
rs4686302 (A218T)	120	0.14	0.019	0.08	0.025
rs237902 (N230N)	120	0.23	0.022	0.17	0.016
rs61740241 (A238T)	119	0.77	0.001	0.53	0.003
rs237902 (N230N) + rs61740241 (A238T)⁴	120	0.03, 0.04	0.055	N/A	N/A
rs4686302 (A218T) + rs61740241 (A238T)⁵	120	N/A	N/A	0.008, 0.01	0.074

¹(A) Logistic regression analysis to predict case/control status and (B) Linear regression analysis to predict gestational age and birth weight.
²The most parsimonious model for predicting case/control status.
³ rs4686302 OR=2.861 (1.041, 7.859) and rs237902 OR=1.803 (0.993, 3.273).
⁴The most parsimonious model for predicting gestational age.
⁵The most parsimonious model for predicting birth weight.

ISSN: 1471-2350