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Table 1 Demographic characteristics of study populations

From: Sequence variants in oxytocin pathway genes and preterm birth: a candidate gene association study

 

SNP genotyping

Resequencing

Case-control3

Maternal triad4

 

U.S.

Argentina

Denmark

U.S.

Argentina

U.S.

N =651

Case ( N =123)

Control ( N =63)

P

Case ( N =723)

Control ( N =920)

P

Case ( N =443)

Control ( N =34)

P

N =187

N =109

GA (weeks) 1

31.1 ± 3.7 (21–36)

33.1 ± 2.5 (27–36)

39.4 ± 0.9 (37–41)

*

33.7 ± 2.8 (20–36)

40

N/A

30.3 ± 3.8 (22–36)

38.9 ± 1.1 (37–41)

*

32.6 ± 3.0 (23–36)

32.0 ± 3.8 (24–36)

           

[Unknown: 5]

 

Infant BW (grams) 1

1739.4 ± 814.7 (332–4610)

1834.8 ± 514 (830–3200)

3514.1 ± 487 (2430–4950)

*

2444 ± 648 (250–5270)

3720.7 ± 457 (2400–5250)

*

1606 ± 791 (332–4400)

3495.2 ± 417.9 (2380–4275)

*

1763.3 ± 527.2 (615–3040)

1967.5 ± 778.2 (597–3691)

           

[Unknown: 5]

 

Infant gender (male/female) 2

373/278

65/57

31/32

0.64

385/338

482/438

0.77

249/194

20/14

0.85

99/87

54/55

           

[Unknown: 1]

 

Maternal age at delivery (years) 1

27.8 ± 6.2 (14–46)

24.7 ± 6.5 (15–48)

26.0 ± 6.1 (16–40)

0.22

29.1 ± 4.4 (17–44)

29.7 ± 4.0 (18–42)

0.001

27.7 ± 6.0 (14–44)

27.9 ± 5.3 (18–40)

0.86

23.2 ± 5.3 (16–39)

30.3 ± 5.2 (18–41)

 

[Unknown: 15]

         

[Unknown: 3]

[Unknown: 11]

  1. 1Data are presented as mean ± standard deviation, with range in parenthesis.
  2. 2Data are presented as counts.
  3. 3Resequencing was also performed on Finnish cases (N=105) and controls (N=95). See the Methods section for a demographic description of this population.
  4. 4Data for Danish maternal triads (N=13) are not shown.
  5. * <0.0001.
  6. GA: gestational age, BW: birth weight, N/A: not available.