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Table 2 CHARGe European ancestry CAC meta-analysis [22] SNP top hits with nominal significance in the African American CAC meta-analysis

From: Genetics of coronary artery calcification among African Americans, a meta-analysis

     

EA CHARGE meta-analysis results (n = 9,992)

AA CAC meta-analysis look-up (n = 5,823)

SNP

Chrom

Position

Closest gene

Role†

Coded allele

Coded allele freq

Effect

SE‡

p‡

Direction of point estimate for the association §

Coded allele

Coded allele freq

Effect

SE

p

Direction of point estimate for the association §

rs3218020

9

21997872

CDKN2A

 

A

0.34

0.19

0.03

2.53E-09

+ + + + +

A

0.15

0.15

0.05

0.002

+ + + - + + - -

rs1537375

9

22116071

CDKN2B

 

T

0.50

−0.24

0.03

5.06E-16

- - - - -

T

0.33

−0.08

0.04

0.03

+ - - - - - - +

rs9349379

6

12903957

PHACTR1

intron

A

0.59

−0.21

0.03

2.65E-11

- - - + -

A

0.90

−0.14

0.08

0.07

- + ? + - - + +

rs4977575

9

22124744

CDKN2B

 

C

0.52

−0.27

0.03

9.93E-19

- - - - -

C

0.12

−0.09

0.05

0.08

- - - + - - - +

rs1333042

9

22103813

CDKN2B

 

A

0.51

−0.24

0.03

4.54E-16

- - - - -

A

0.12

−0.09

0.05

0.09

+ - - - + - - -

rs10511701

9

22112599

CDKN2B

 

T

0.49

−0.24

0.03

4.48E-16

- - - - -

T

0.28

−0.07

0.04

0.09

+ - - - + - - +

  1. †If no role indicated, then is outside known gene boundaries.
  2. ‡SE: Standard error; p: p-value.
  3. §Order of studies: for EA CHARGE: Age, Gene/Environment Susceptibility Study—Reykjavik (AGES), Rotterdam Study-II, Framingham Heart Study, GENOA, Rotterdam Study-I; and for AA CAC: FamHS, JHS, CARDIA, JHS-ARIC, MESA, MESA Family/Air, GeneSTAR, GENOA. GWAS results from each study were completed independently, thus data availability varied by study depending on study specific imputation quality and genotyping quality control for each SNP. Therefore not all studies had results for all SNPs.