Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study

Fesinmeyer, Megan D; North, Kari E; Lim, Unhee; Bůžková, Petra; Crawford, Dana C; Haessler, Jeffrey; Gross, Myron D; Fowke, Jay H; Goodloe, Robert; Love, Shelley-Ann; Graff, Misa; Carlson, Christopher S; Kuller, Lewis H; Matise, Tara C; Hong, Ching-Ping; Henderson, Brian E; Allen, Melissa; Rohde, Rebecca R; Mayo, Ping; Schnetz-Boutaud, Nathalie; Monroe, Kristine R; Ritchie, Marylyn D; Prentice, Ross L; Kolonel, Lawrence N; Manson, JoAnn E; Pankow, James; Hindorff, Lucia A; Franceschini, Nora; Wilkens, Lynne R; Haiman, Christopher A; Le Marchand, Loic; Peters, Ulrike

doi:10.1186/1471-2350-14-6

Table 2 Complete meta-analysis results in European Americans, effect size expressed in terms of % difference in mean BMI

From: Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study

					Current smokers			Former/never smokers			Combined sex and smoking status*
Gene	SNP	CA	sex	p-value for interaction	% difference in mean BMI (95% CI)	p-value	N	% difference in mean BMI (95% CI)	p-value	N	% difference in mean BMI (95% CI)	p-value	N	AF
MTCH2	rs10838738	G	F	0.40	0.6 (-0.4 - 1.51)	0.23	2404	0.4 (-0.2 - 1.11)	0.20	17737	0.51 (0.22 - 0.8)	1.0E-03	34679	0.35
MTCH2	rs10838738	G	M	0.24	0.3 (-0.5 - 1.11)	0.40	1525	0.8 (0.1 - 1.41)	0.03	4945	0.51 (0.22 - 0.8)	1.0E-03	34679	0.35
GNPDA2	rs10938397	G	F	0.87	0.1 (-1.39 - 1.61)	0.88	2165	0.3 (-0.3 - 1.01)	0.28	15961	0.29 (0.004 - 0.69)	0.04	31346	0.43
GNPDA2	rs10938397	G	M	0.63	0.1 (-1 - 1.31)	0.82	1398	0.5 (-0.2 - 1.21)	0.13	3753	0.29 (0.004 - 0.69)	0.04	31346	0.43
KCTD15	rs11084753	G	F	0.42	0.8 (0.004 - 1.61)	0.05	3447	−0.1 (-0.7 - 0.4)	0.60	21303	0.11 (-0.18 - 0.4)	6.1E-01	29411	0.67
KCTD15	rs11084753	G	M	0.46	−0.1 (-0.7 - 0.6)	0.78	2321	0.2 (-0.3 - 0.7)	0.42	7901	0.11 (-0.18 - 0.4)	6.1E-01	29411	0.67
MC4R	rs12970134	A	F	0.30	0.5 (-0.6 - 1.61)	0.38	1619	0.6 (-0.3 - 1.41)	0.20	14992	0.8 (0.29 - 1.2)	1.3E-03	21987	0.26
MC4R	rs12970134	A	M	0.64	0.1 (-0.9 - 1.11)	0.85	672	1.11 (-0.3 - 2.53)	0.12	2492	0.8 (0.29 - 1.2)	1.3E-03	21987	0.26
MC4R	rs17782313	C	F	0.60	0.8 (-0.1 - 1.61)	0.09	3449	0.7 (0.1 - 1.31)	0.02	21334	0.22 (-0.004 - 0.51)	0.08	35398	0.22
MC4R	rs17782313		M	0.83	0.1 (-0.6 - 0.8)	0.72	2326	0.6 (0.002 - 1.21)	0.05	7930	0.22 (-0.004 - 0.51)	0.08	35398	0.22
NEGR1	rs2815752	T	F	0.45	0.7 (-0.1 - 1.51)	0.07	3393	0.2 (-0.3 - 0.7)	0.38	20898	0.51 (0.11 - 0.8)	9.2E-03	28261	0.63
NEGR1	rs2815752	T	M	0.96	0.4 (-0.3 - 1.11)	0.30	2272	0.1 (-0.4 - 0.6)	0.69	7363	0.51 (0.11 - 0.8)	9.2E-03	28261	0.63
TMEM18	rs6548238	C	F	0.15	1.11 (0.2 - 2.12)	0.02	3424	1.21 (0.5 - 1.82)	7.0E-04	21261	1.02 (0.62 - 1.42)	8.6E-08	37061	0.83
TMEM18	rs6548238	C	M	0.69	0.7 (-0.2 - 1.51)	0.12	2290	0.9 (0.2 - 1.51)	0.01	7805	1.02 (0.62 - 1.42)	8.6E-08	37061	0.83
SH2B1	rs7498665	G	F	0.47	0.7 (-0.2 - 1.61)	0.11	2400	0.9 (0.3 - 1.51)	6.0E-03	17698	0.22 (-0.11 - 0.62)	2.2E-01	31383	0.38
SH2B1	rs7498665	G	M	0.49	0.2 (-0.6 - 1.01)	0.67	1530	0.8 (0.1 - 1.51)	0.02	4948	0.22 (-0.11 - 0.62)	2.2E-01	31383	0.38
FTO	rs9939609	A	F	0.08	1.71 (0.9 - 2.53)	3.5E-05	2719	0.6 (-0.01 - 1.11)	0.05	18221	1.31 (1.02 - 1.71)	4.6E-15	28286	0.40
			M	0.94	1.31 (0.6 - 1.92)	2.8E-04	1457	1.51 (1.01 - 2.12)	6.9E-08	5671

CA Coded allele, M male, F female, CI confidence interval, AF coded allele frequency.

Back to article page

ISSN: 1471-2350

Contact us

General enquiries: ORSupport@springernature.com

BMC Medical Genetics

Contact us