Table 3 Summary of PALB2 c. 2323C>T [p.Q775X] carriers identified in studies of French Canadian cancer families or cases

0

22

HBC and HBOC families; BRCAPRO scores > 0.10

Mutation-negative families

[10]

0

16

HBC and HBOC families; BRCAPRO scores < 0.10

Mutation-negative families

[10]

1

BC 54 [P28031¹ and (F1573²)]

50

BC < 50 years of age, or BC between 50–65 yrs of age with at least one other BC or OC in first or second degree relative

Mutation-negative families

[5] ([22])

2

BC 36 [P26007¹] BC 49 [P31030¹]

356²

BC <50 years

Common French Canadian mutation negative

[5]

4

BC 36 [P26007¹] BC 46 [P28031¹] BC 49 [P31030¹] BC 49 [P36470]

564²

BC <50 years

Common French Canadian mutation negative

[29]

0

99

High risk BC families

Mutation negative

[31]

0

21

HBC and HBOC families with at least 2 first/second degree relatives with BC

Mutation negative

[2]

1

BiBC 39–42 [F1469]

48

HBC families (see Table 1)

Mutation-negative or common French Canadian mutation negative

This study

0

23

HBOC families (see Table 1)

Mutation-negative or common French Canadian mutation negative

This study

1

BC52;OC58

491

OC (see Table 2)

Not known

This study