Figure 2

TESS Analysis of potential transcription factor binding. The T variant allele creates potential for EFII and C/EBPalpha binding. A) The rs7559955 allele in intron 1 is found in a region of high conservation. Alignments of the homologous region from human, chimpanzee, macaque, mouse, rat, dog, and cow were performed, and the region of high conservation, and thus high regulatory potential as determined by ESPERR, is marked in blue. B) Transcription factor binding site analysis using TESS indicates that the presence of the T allele may confer the addition of EFII or C/EBPalpha transcription factor binding sites.