Figure 1

Haploview analysis of SNPs in MARCO [GeneID: 8685], located on chromosome 2q12. Linkage Disequilibrium (LD) in the African population is visualized across the MARCO locus, including upstream and downstream regions (chr2: 119414167–119468337). Polymorphisms are identified by their dbSNP rs numbers, and their position relative to the gene structure is marked. SNPs marked in bold were typed in this study. SNPs marked in green were included in the Wellcome Trust Case Control consortium [32] analysis and were used in validation studies. Empty squares indicate a high degree of LD (LD coefficient D' = 1) between pairs of markers. Numbers indicate the D' value expressed as a percentile. Black squares indicate pairs in strong LD with logarithm of odds (LOD) scores for LD ≥2; grey squares, D' < 1 with LOD ≥2; white squares, D' < 1.0 and LOD < 2.