The associations between the polymorphisms in the CTLA-4gene and the risk of Graves’ disease in the Chinese population

Table 2 Distribution of CTLA-4 genotype among patients with Graves’ disease and controls included in the meta-analysis

Polymorphism	Author	Case			Control			Case		Control		HWE
+49A/G polymorphism		AA	AG	GG	AA	AG	GG	A	G	A	G
	Du, Y T [11]	1	27	68	7	26	27	29	163	40	80	Yes
	Guo, Z Q [12]	24	52	26	41	47	12	100	104	129	71	Yes
	Han, S Z [2]	33	95	135	32	89	75	161	365	153	239	Yes
	Jiang, B R [13]	10	44	44	33	46	16	64	132	112	78	Yes
	Shen, F X [15]	5	34	68	4	30	23	44	170	38	76	Yes
	Wang, L [17]	3	47	37	32	42	10	53	121	106	62	Yes
	Wang, P W [18]	15	69	124	18	77	97	99	317	113	271	Yes
	Wang, Q H [19]	21	24	19	12	15	1	66	62	39	17	Yes
	Weng, Y C [21]	8	53	46	15	58	28	69	145	88	114	Yes
	Wang, S Q [20]	5	47	38	24	52	14	57	123	100	80	Yes
	Yang, J [22]	12	139	152	29	97	89	163	443	155	275	Yes
	Yao, B [23]	9	53	58	11	57	55	71	169	79	167	Yes
	Yu, Q L [24]	13	36	51	28	46	26	62	138	102	98	Yes
	Yu, Z Y [25]	13	45	67	20	60	46	71	179	100	152	Yes
	Zhang, J L [27]	16	100	70	32	43	25	132	240	107	93	Yes
	Zhang, Q [28]	2	29	58	7	26	27	33	145	40	80	Yes
	Zhao, S X [5]	104	730	1030	156	823	945	938	2790	1135	2713	Yes
−318C/T polymorphism		CC	CT	TT	CC	CT	TT	C	T	C	T
	Chong, K K [10]	147	28	2	122	29	0	322	32	273	29	Yes
	Du, Y T [11]	80	13	3	46	12	2	173	19	104	16	Yes
	Guo, Z Q [12]	84	18	0	76	23	1	186	18	175	25	Yes
	Kang, Y Z [14]	52	8	1	48	11	1	112	10	107	13	Yes
	Zhang, H [26]	175	35	1	69	16	0	385	37	154	16	Yes
	Han, S Z [2]	159	98	2	103	85	2	416	26	291	101	Yes
	Zhang, Q [28]	65	22	6	46	12	8	152	110	104	16	Yes
CT60 polymorphism		GG	AG	AA	GG	AG	AA	G	A	G	A
	Chong, K K [10]	125	48	4	88	51	12	298	56	227	75	Yes
	Han, S Z [2]	184	71	8	123	60	13	439	87	306	86	Yes
	Tsai, S T [16]	136	48	5	372	216	32	320	58	960	280	Yes
	Wang, P W [18]	138	46	5	125	58	9	322	56	308	76	Yes

ISSN: 1471-2350