Table 4 Genotypes and odds ratios in age-related macular degeneration (AMD) and normal patients with risk allele, assuming a dominant effect

ARMS2 Homozygous T (risk)

11/60 (18%)

19/101 (19%)

30/161 (19%)

10/164 (6%)

ARMS2 Homozygous G

21/60 (35%)

24/101 (24%)

45/161 (28%)

83/164 (51%)

ARMS2 Heterozygous

28/60 (47%)

58/101 (57%)

86/161 (53%)

71/164 (43%)

OR (p-value)

1.81 (0.07)

3.13 (0.0001)

4.72 (0.00001)

CFH Homozygous C (risk)

11/55 (20%)

18/94 (19%)

29/97 (20%)

16/163 (9.8%)

CFH Homozygous T

23/55 (42%)

29/94 (31%)

52/97 (35%)

85/163 (52%)

CFH Heterozygous

21/55 (38%)

47/94 (50%)

68/97 (45%)

62/163 (38%)

OR (p-value)

1.27 (0.54)

2.05 (0.014)

1.71 (0.027)