Schematic diagram representing novel CYP2D6*4P , *84 , *85 and *86 alleles identified in the South African cohort described in this study. Polymorphisms are represented by black blocks. Allele defining polymorphism are indicated by a white star. These alleles have been accepted by the CYP Allele Nomenclature Committee for CYP2D6 (http://www.imm.ki.se/CYPalleles/). CYP2D6*2A and *4 used for comparison, were adopted from Gaedigk et al. . BL: Black African; CA: Caucasian; IN: Indian; UTR: untranslated region; Ex: exon; In: intron.