Table 3 Epistatic interactions between genetic variants associated with blood pressure
From: Epistatic study reveals two genetic interactions in blood pressure regulation
A: Epistatic interactions in Discovery population betweenVCAM1 (rs1041163) * APOB (rs1367117) on SBP (P=0.04) | |||||
|---|---|---|---|---|---|
SBP | rs1041163 | ||||
| Â | 11 | 12 | 22 | N TOT | |
rs1367117 | 11 | 141.47 ± 21.31 (487) | 138.55 ± 22.08 (213) | 152.55 ± 19.69 (30) | 730 |
12 | 137.27 ± 21.22 (468) | 140.67 ± 21.27 (182) | 146.15 ± 20.68 (28) | 678 | |
22 | 139.78 ± 19.24 (111) | 135.43 ± 24.96 (41) | 139.83 ± 26.73 (8) | 160 | |
| Â | N TOT | 1066 | 436 | 66 | 1568 |
B: Epistatic interactions in Discovery population between VCAM1 (rs1041163) * APOB (rs1367117) on DBP (P=0.027) | |||||
DBP | rs1041163 | ||||
11 | 12 | 22 | N TOT | ||
rs1367117 | 11 | 86.77 ± 14.47 (495) | 85.35 ± 13.10 (232) | 87.95 ± 14.22 (37) | 764 |
12 | 87.97 ± 14.05 (436) | 92.11 ± 11.99 (149) | 88.04 ± 13.41 (21) | 606 | |
22 | 90.06 ± 14.08 (135) | 87.92 ± 11.19 (55) | 96.00 (8) | 198 | |
| Â | N TOT | 1066 | 436 | 66 | 1568 |
C: Epistatic interactions in Discovery population between SCGB1A1 (rs3741240) * LPL (rs1800590) on SBP (P=0.02) | |||||
SBP | rs3741240 | ||||
11 | 12 | 22 | N TOT | ||
rs1800590 | 11 | 87.66 ± 14.31 (846) | 87.14 ± 14.25 (739) | 87.95 ± 14.22 (217) | 1802 |
12 | 86.85 ± 13.89 (46) | 94.14 ± 11.41 (34) | 88.04 ± 13.41 (11) | 91 | |
22 | (0) | 99.30 ± 2.45 (4) | 96.00 (1) | 5 | |
| Â | N TOT | 892 | 777 | 229 | 1898 |
D: Epistatic interactions in Discovery population between SCGB1A1 (rs3741240) * LPL (rs1801177) on DBP (P=0.03) | |||||
DBP | rs3741240 | ||||
11 | 12 | 22 | N TOT | ||
rs1801177 | 11 | 87.66 ± 14.36 (856) | 87.32 ± 14.22 (751) | 88.05 ± 14.19 (219) | 1826 |
12 | 86.55 ± 12.38 (36) | 92.91 ± 12.23 (26) | 85.65 ± 13.72 (9) | 71 | |
22 | (0) | (0) | 96.00 (1) | 1 | |
| Â | N TOT | 892 | 777 | 229 | 1898 |
E: Epistatic interactions in Replication population between VCAM1 (rs1041163) * APOB (rs1367117) on DBP (P=0.045) | |||||
DBP | rs1041163 | ||||
11 | 12 | 22 | N TOT | ||
rs1367117 | 11 | 81.73 ± 0.47 (509) | 80.80 ± 0.74 (241) | 85.00 ± 2.07 (29) | 779 |
12 | 80.88 ± 0.49 (441) | 80.55 ± 0.84 (183) | 78.25 ± 2.69 (30) | 654 | |
22 | 80.05 ± 1.11 (92) | 83.71 ± 1.81 (46) | 83.16 ± 3.19 (6) | 144 | |
| Â | N TOT | 1042 | 470 | 65 | 1577 |
F: Epistatic interactions in Replication population between SCGB1A1 (rs3741240) * LPL (rs1801177) on DBP (P=0.05) | |||||
DBP | rs3741240 | ||||
11 | 12 | 22 | N TOT | ||
rs1800590 | 11 | 80.58 ± 0.41 (681) | 81.62 ± 0.41 (684) | 81.09 ± 0.90 (168) | 1533 |
12 | 83.60 ± 2.04 (29) | 81.76 ± 1.94 (21) | 86.31 ± 3.02 (11) | 61 | |
22 | 60.00 (1) | 78.75 ± 1.2 (2) | (0) | 3 | |
| Â | N TOT | 711 | 707 | 179 | 1597 |