Table 2 Genetic variants associated with blood pressure
From: Epistatic study reveals two genetic interactions in blood pressure regulation
Gene | OMIM accession number | SNP | Ancestral alleles | Type | MAF | p-value | p-value adjusted | Beta | SE | Trait |
|---|---|---|---|---|---|---|---|---|---|---|
AGTR 1 | *106165 | rs5186 | A | 3’UTR | 28.933 | 8.34×10-04 | 0.027 | −0.051 | 0.032 | SBP |
6.96×10-03 | 0.041 | −0.045 | 0.051 | DBP | ||||||
CSF2 | *138960 | rs25882 | T | Exonic | 25.596 | 4.67×10-06 | 3.83×10-04 | 0.124 | 0.030 | SBP |
7.25×10-07 | 5.94×10-05 | 0.148 | 0.048 | DBP | ||||||
F7 | 227500 | rs5742910 | NA | Upstream | 15.024 | 3.72×10-04 | 0.030 | −0.028 | 0.041 | SBP |
3.34×10-04 | 0.027 | −0.042 | 0.065 | DBP | ||||||
rs6046 | C | Exonic | 12.874 | 5.33×10-04 | 0.044 | −0.028 | 0.044 | SBP | ||
IL1B | *147720 | rs1143634 | C | Exonic | 19.397 | 4.21×10-04 | 0.035 | −0.044 | 0.035 | SBP |
5.92×10-04 | 0.049 | −0.052 | 0.056 | DBP | ||||||
LDLR | 606945 | rs5742911 | A | 3’UTR | 32.308 | 4.31×10-04 | 0.035 | 0.06 | 0.029 | SBP |
1.17×10-04 | 0.010 | 0.071 | 0.047 | DBP | ||||||
LPL | 609708 | rs1800590 | G | 5’UTR | 2.586 | 3.46×10-04 | 0.028 | 0.076 | 0.088 | SBP |
TGFB1 | *190180 | rs1800469 | C | Upstream | 29.048 | 4.44×10-04 | 0.036 | −0.026 | 0.030 | SBP |
9.77×10-06 | 8.02×10-04 | −0.038 | 0.047 | DBP | ||||||
VDR | *601769 | rs2228570 | T | Exonic | 40.139 | 1.16×10-05 | 9.48×10-04 | −0.012 | 0.028 | SBP |
6.02×10-06 | 4.93×10-04 | −0.009 | 0.045 | DBP |