The 3′-UTR of the adiponectin Q gene harbours susceptibility loci for atherosclerosis and its metabolic risk traits

Table 3 Sharing of adiponectin Q haplotypes by cardiovascular risk traits

SNP block	Haplotype	Trait	Pooled	Controls	Cases	χ²	P-value
1-8	GTGCCTCA	MI	0.025	0.022	0.029	4.13	0.042
		HTN	0.025	0.021	0.029	6.40	0.011**
		OBS	0.024	0.020	0.027	5.18	0.023*
1-7	GTGCCTC	CAD	0.025	0.021	0.030	7.17	0.007**
		MI	0.025	0.023	0.030	4.41	0.036
		HTN	0.025	0.021	0.030	7.17	0.007**
		OBS	0.025	0.020	0.028	6.19	0.013**
1-6	GTGCCT	MI	0.025	0.023	0.030	4.40	0.036
		HTN	0.025	0.021	0.030	7.19	0.007**
		OBS	0.025	0.020	0.028	5.51	0.019**
1-5	GTGCC	MI	0.027	0.025	0.032	4.86	0.028
		HTN	0.027	0.023	0.032	6.46	0.011**
		OBS	0.026	0.022	0.029	4.22	0.040
1-4	GTGC	MI	0.028	0.025	0.033	5.06	0.025
		HTN	0.028	0.023	0.032	6.60	0.010**
		OBS	0.027	0.023	0.030	4.19	0.041
5-8	TCCA	OBS	0.025	0.029	0.022	4.95	0.026
		lHDL	0.025	0.021	0.029	5.06	0.025

The table lists some of the shared haplotypes constructed from the studied variants, rs224176 (1), rs6444174 (2), rs6773957 (3), rs1063537 (4), rs2082940 (5), rs4686804 (6), rs1063539 (7) and rs9842733 (8), arranged sequentially by their chromosomal positions. The most frequent 8-mer haplotype TTACCCCA (0.344) was employed as the baseline to determine the relative effects of these haplotypes. The pooled, control and case haplotype frequencies are proportions. SNP blocks represent the range of variants constituting the respective haplotypes. CAD, coronary artery disease; MI, myocardial infarction; HTN, hypertension; OBS, obesity; lHDL, low high density lipoprotein. *P < 0.02 and **P < 0.01 by χ² test.

ISSN: 1471-2350