Skip to main content

Table 1 Genetic association with CP

From: Sequencing of the IL6 gene in a case–control study of cerebral palsy in children

rs ID

Position

Homozygote vs. wt

OR

95% CI

P

Bonf

 

rs1800795

−174

C/C versus G/G

2.5

1.4-4.6

0.002

0.03

Promoter

rs2069832

615

A/A versus G/G

2.7

1.4-5.5

0.001

0.02

Intron

rs2069833

846

C/C versus T/T

2.4

1.3-4.6

0.004

0.05

Intron

rs1474348

1090

C/C versus G/G

1.5

0.6-3.6

0.33

1

Intron

rs1474347

1306

C/C versus A/A

1.8

0.8-3.6

0.1

0.9

Intron

rs1554606

1889

T/T versus G/G

2.5

1.5-4.5

0.0005

0.007

Intron

rs2069845

3331

G/G versus A/A

2.3

1.2-4.3

0.009

0.09

CpG site*

4-SNP haplotype block a

 

3.0

1.5-6.0

0.0007

0.004

 

7-SNP haplotype block b

 

4.3

2.0-10.1

0.00007

0.0004

 

rs ID

Position

Homozygote vs. wt

OR

95% CI

P

Bonf

 

rs1800795

−174

C/G versus G/G

1.3

0.8-2.0

0.33

1

Promoter

rs2069832

615

A/G versus G/G

1.3

0.8-2.0

0.28

1

Intron

rs2069833

846

C/T versus T/T

1.4

0.9-2.1

0.19

1

Intron

rs1474348

1090

C/G versus G/G

1

0.6-1.7

1

1

Intron

rs1474347

1306

C/A versus A/A

0.7

0.3-1.8

0.5

1

Intron

rs1554606

1889

T/G versus G/G

1.1

0.8-1.7

0.5

1

Intron

rs2069845

3331

G/A versus A/A

1

0.5-2.3

1

1

CpG site*

4-SNP haplotype block a

 

1

0.6-1.6

1

1

 

7-SNP haplotype block b

 

1

0.5-1.7

0.9

1

 
  1. *[27]; wt = wildtype; OR = odds ratio; CI = confidence interval; Bonf = Bonferroni correction for multiple hypothesis testing. For SNPs, correction was done for 14 total common SNPs tested.
  2. aThe 4-SNP block includes rs1800795, rs2069832, rs2069833, rs1474348. It was one of five haplotypes identified in African American controls. Bonferroni correction for five hypotheses tested.
  3. bThe 7-SNP block includes all SNPs listed in table. It was one of five haplotypes identified in white controls, one of three in Hispanic controls, and one of three in Asian controls. Bonferroni correction for 5 hypotheses tested.