Vitamin D-responsive SGPP2 variants associated with lung cell expression and lung function

BMC Medical Genetics

Table 4 The association of SNPs in vitamin D-responsive genes (nominal P < 2.0 × 10 ^-02 ) with FEV ₁ (mL) for African-Americans in the Health, Aging and Body Composition study (sorted by gene)*

Gene	RS#	Chr	Coded allele	MAF (%)	β**	SE	Nominal P	Model
*DAPK1*	rs3128491	9	G	33	51.48	21.4	1.65 × 10^-02	A
*FSTL1*	rs4676781	3	T	8	-110.13	35.3	1.88 × 10^-03	A
	rs13100865	3	G	9	-105.96	35.0	2.54 × 10^-03	A
	rs13097755†	3	T	28	-60.46	21.6	5.20 × 10^-03	A
*KAL1*	rs6530200	23	T	47	-45.28	16.8	7.20 × 10^-03	A
	rs974655	23	A	49	79.23	30.3	9.14 × 10^-03	D
*KCNS3*	rs1031771†	2	A	16	243.76	83.5	3.60 × 10^-03	R
*RSAD2*	rs4669114††	2	G	10	-119.55	36.2	9.93 × 10^-04	D
	rs6431837	2	C	47	-101.06	33.6	2.66 × 10^-03	R
	rs7570384	2	C	38	-55.35	20.1	5.88 × 10^-03	A
	rs4669111	2	A	41	-49.75	20.1	1.34 × 10^-02	A
*SGPP2*	rs4528748††	2	C	27	-209.95	54.1	1.11 × 10^-04***	R

*Abbreviations: Chr, chromosome; MAF, minor allele frequency; β, regression coefficient; SE, standard error; A = additive genetic model, D = dominant model, R = recessive model.
**Beta-coefficient estimates the association of allele with FEV₁, based on genetic model shown, adjusted for age, height, smoking, gender, study site, and ancestry principal components.
***FDR q-value <0.05.
†one redundant SNP not shown.
††two redundant SNPs not shown.

ISSN: 1471-2350