Potential contribution of SIM2 and ETS2 functional polymorphisms in Down syndrome associated malignancies

Chatterjee, Arpita; Dutta, Samikshan; Mukherjee, Sanjit; Mukherjee, Nupur; Dutta, Avirup; Mukherjee, Ashis; Sinha, Swagata; Panda, Chinmay Kumar; Chaudhuri, Keya; Roy, Ananda L; Mukhopadhyay, Kanchan

doi:10.1186/1471-2350-14-12

BMC Medical Genetics

Table 8 Individual and interactive effects of SIM2 and ETS2 SNPs in different malignant groups (analyzed by MDR 2.0 beta 8.1)

From: Potential contribution of SIM2 and ETS2 functional polymorphisms in Down syndrome associated malignancies

	Interactive effects
SNP ID (individual effect)	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15
ALL
rs2073601 (3.69)	-	−4.91	−3.23	−1.16	−0.45	−3.42	−1.34	−1.41	−2.55	−2.33	−2.33	−2.45	−2.45	−2.13	−4.27
rs2073416 (2.95)		-	−1.55	−1.00	−1.97	−2.21	−1.99	−2.25	−2.44	−1.98	−1.98	−2.12	−2.12	−1.58	−3.53
rs2269188 (2.56)			-	0.74	−0.29	−0.01	0.79	0.16	−0.47	−0.25	−0.25	−0.22	−0.22	−0.31	−2.15
rs461155 (0.07)				-	0.21	−0.53	−0.37	0.30	−0.63	−0.39	−0.39	−0.21	−0.21	−0.29	−0.65
rs1051425 (0.65)					-	−0.31	−0.13	−0.52	−0.06	0.18	0.18	0.07	0.07	−0.26	−0.74
rs374575 (1.03)						-	−1.08	−1.18	−1.15	−1.14	−1.14	−0.89	−0.89	−1.06	−0.69
rs2070529 (0.73)							-	−1.04	−0.91	−0.16	−0.16	0.48	0.48	0.91	−1.15
rs2070530 (0.64)								-	−1.10	−0.90	−0.90	0.15	0.15	1.87	−1.06
rs2070531 (0.95)									-	−1.13	−1.13	1.44	1.44	2.53	−1.23
rs6517481 (0.58)										-	−1.09	2.21	2.21	2.90	−1.00
rs7276961 (0.58)											-	2.21	2.21	2.90	−1.00
rs1051475 (0.39)												-	−0.57	2.52	−0.97
rs1051476 (0.39)													-	2.52	−0.97
rs11254 (0.63)														-	−0.97
rs711 (3.55)															-
BC
rs2073601 (3.50)	-	−4.62	−3.32	−3.69	−3.32	−3.33	−3.89	−3.12	−3.03	−2.66	−2.66	−1.97	−1.97	−0.76	−3.03
rs2073416 (2.17)		-	−2.10	−2.36	−1.86	−1.78	−4.05	−3.14	2.60	2.47	2.47	1.90	1.90	−0.80	−1.56
rs2269188 (0.92)			-	−2.70	1.66	0.07	−1.09	−0.14	−2.90	−2.77	−2.77	−0.96	−0.96	−1.45	0.02
rs461155 (15.15)				-	−0.77	−3.55	−3.99	−3.22	−4.20	−4.07	−4.07	−1.19	−1.19	−1.31	−7.00
rs1051425 (0.58)					-	−2.71	−1.57	−0.97	−0.97	−1.50	−1.50	0.37	0.37	−0.66	−1.16
rs374575 (4.04)						-	−5.88	−5.44	−3.83	−4.28	−4.28	−2.39	−2.39	−2.19	−3.01
rs2070529 (3.79)							-	−5.97	−3.87	−5.35	−5.35	−1.63	−1.63	−0.79	−2.14
rs2070530 (3.03)								-	−4.90	−5.15	−5.15	−1.54	−1.54	0.33	−1.63
rs2070531 (4.01)									-	−4.91	−4.91	2.19	2.19	3.81	−2.37
rs6517481 (3.88)										-	−5.09	0.86	0.86	3.94	−1.95
rs7276961 (3.88)											-	0.86	0.86	3.94	−1.95
rs1051475 (1.00)												-	−1.23	7.32	0.19
rs1051476 (1.00)													-	7.32	0.19
rs11254 (1.12)														-	−1.36
rs711 (4.56)															-
OC
rs2073601 (2.04)	-	−0.91	−1.51	−2.04	−0.62	−1.12	−0.79	−0.79	−1.14	−1.27	−1.27	−1.46	−1.46	−1.38	−2.44
rs2073416 (0.04)		-	0.21	−0.41	−0.25	−1.23	0.24	1.00	−0.58	−0.37	−0.37	1.27	1.27	0.42	−1.05
rs2269188 (0.81)			-	−1.17	0.45	−0.52	−0.49	−0.35	−0.97	−0.94	−0.94	−0.17	−0.17	−0.26	−1.31
rs461155 (13.14)				-	−0.70	−1.58	−0.64	−0.38	−1.83	−1.69	−1.69	0.38	0.38	−0.47	−1.26
rs1051425 (0.34)					-	−1.38	−0.77	−0.76	−1.37	−1.07	−1.07	−0.05	−0.05	−0.20	−1.23
rs374575 (1.89)						-	−2.33	−2.23	−1.45	−1.50	−1.50	−1.56	−1.56	−0.97	−2.66
rs2070529 (1.16)							-	−1.34	−1.78	−1.47	−1.47	−1.05	−1.05	−0.35	−1.52
rs2070530 (0.91)								-	−1.68	−1.31	−1.31	−1.92	−1.92	−0.44	−1.63
rs2070531 (1.47)									-	−2.48	−2.48	1.90	1.90	0.67	−2.13
rs6517481 (1.33)										-	−2.40	−1.46	−1.46	0.03	−1.99
rs7276961 (1.33)											-	−1.46	−1.46	0.03	−1.99
rs1051475 (0.48)												-	−0.69	1.33	−0.73
rs1051476 (0.48)													-	1.33	−0.73
rs11254 (0.11)														-	−0.51
rs711 (2.26)															-

1 = rs2073601, 2 = rs2073416, 3 = rs2269188, 4 = rs461155, 5 = rs1051425, 6 = rs374575, 7 = rs2070529, 8 = rs2070530, 9 = rs2070531, 10 = rs6517481, 11 = rs7276961, 12 = rs1051475, 13 = rs1051476, 14 = rs11254, 15 = rs711 (Entropy values mentioned in bold are in synergistic interaction).

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