Table 3 Target genes of SIM2/ETS2 and their probable function identified by in silico analysis

A4GALT

Carbohydrate metabolic process, lipid metabolic process, protein metabolic process

ABCB8

Immune system process, extracellular transport, carbohydrate metabolic process, response to toxin

ABP1

Oxidoreductase activity, immune system process, cellular amino acid and derivative metabolic process

ATP1A1

Hydrolase activity, cation transmembrane transporter activity, ion channel activity, cation transport, lipid transport, lipid metabolic process, cellular calcium ion homeostasis

ATP1A4

Cation transport, lipid transport, lipid metabolic process, homeostasis

C1QL1

Complement activation, carbohydrate transport, signal transduction, cell-cell signaling, cell adhesion, carbohydrate metabolic process, lipid metabolic process, cellular component morphogenesis, mesoderm development, skeletal system development, response to stimulus

C4BPA

Complement activation, signal transduction, cell-cell adhesion, protein metabolic process, blood coagulation

C4BPB

Complement activation, signal transduction, cell-cell adhesion, protein metabolic process, blood coagulation

CEACAM1

Signal transduction, cell-cell adhesion

CYB561

Oxidoreductase activity, respiratory electron transport chain

EMCN

Cell adhesion

EXOSC2

Nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

FVT1

Oxidoreductase activity, metabolic process

FXYD5

Ion channel activity, protein binding ion transport, signal transduction

GATA3

Hydrolase activity, acting on ester bonds, DNA binding, transcription factor activity nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, endoderm development, heart development, hemopoiesis

GNB2L1

Intracellular protein transport, signal transduction

GTF3C5

DNA binding, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

H1F0

Nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, organelle organization, establishment or maintenance of chromatin architecture

HLA-DOA

Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II, cellular defense response

HPD

Cellular amino acid and derivative metabolic process

HRB2

RNA binding, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

KDELR2

Intracellular protein transport, exocytosis

KLK8

Spermatogenesis, immune system process, cell cycle, protein metabolic process, cell cycle, ectoderm development, nervous system development, blood coagulation

KRT16

Structural constituent of cytoskeleton, ectoderm development, cellular component morphogenesis

LCK

Female gamete generation, immune system process, carbohydrate transport, apoptosis, cell cycle, cell surface receptor linked signal transduction, intracellular signaling cascade, carbohydrate metabolic process, protein metabolic process, cell motion, signal transduction, cell-cell signaling, cell-cell adhesion, ectoderm development, mesoderm development, embryonic development, angiogenesis, nervous system development, response to stress

LDLR

female gamete generation, cell adhesion

LPPR4

Cell surface receptor linked signal transduction, phosphate metabolic process, lipid metabolic process, signal transduction

MAG

Receptor activity, structural constituent of myelin sheath, receptor binding, B cell mediated immunity, cell surface receptor linked signal transduction, cell-cell adhesion, signal transduction, cell-cell adhesion, ectoderm development, nervous system development, response to stimulus

MAGEA3

Gamete generation, induction of apoptosis, cell adhesion

MAGEE1

Gamete generation, induction of apoptosis, cell adhesion

MASP1

Complement activation, protein metabolic process, response to stimulus

MLX

DNA binding, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, transcription factor activity

MOGAT1

Acyl-CoA metabolic process, lipid metabolic process

MRPL37

Protein metabolic process

MRPS12

Protein metabolic process

NAT5

Acyltransferase activity, protein metabolic process

NDUFA2

Oxidoreductase activity, oxidative phosphorylation, respiratory electron transport chain

PCSK4

Peptidase activity, cell surface receptor linked signal transduction, cell-matrix adhesion, protein metabolic process, signal transduction

PDE6D

Visual perception, sensory perception, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

PRSS8

Peptidase activity, spermatogenesis, immune system process, protein metabolic process

RELA

B cell mediated immunity, negative regulation of apoptosis, cell cycle, intracellular signaling cascade, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, signal transduction, cellular defense response

RER1

Intracellular protein transport

S100A8

Calcium ion binding, receptor binding, calmodulin binding, immune response, macrophage activation, cell cycle, intracellular signaling cascade, cell motion, cell cycle, signal transduction, response to stimulus

S100A9

Immune response, macrophage activation, cell cycle, intracellular signaling cascade, cell motion, cell cycle, signal transduction, response to stimulus

SCARB1

Receptor activity, macrophage activation, lipid transport, apoptosis, signal transduction, cell adhesion, lipid metabolic process, cellular component morphogenesis

SERPINA1

Protein metabolic process

SFRS1

RNA splicing factor activity, transesterification mechanism, RNA binding, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

SLC25A21

Cation transport, phosphate transport, lipid transport, nucleobase, nucleoside, nucleotide and nucleic acid transport, phosphate metabolic process, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, lipid metabolic process

SLC7A9

Amino acid transmembrane transporter activity, transmembrane transporter activity amino acid transport, cellular amino acid and derivative metabolic process

SP1

Immune system process, nucleoside, nucleotide and nucleic acid metabolic process

TGM2

Protein metabolic process

TH

Oxidoreductase activity, signal transduction, cellular amino acid and derivative metabolic process

THBS1

Receptor binding, enzyme regulator activity, immune system process, blood coagulation

TRFP

Ubiquitin-protein ligase activity

TRRAP

Immune system process, induction of apoptosis, cell cycle, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, protein metabolic process, cell cycle, signal transduction, organelle organization, establishment or maintenance of chromatin architecture, response to stress