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Table 4 Association between minor ACE2 alleles and blood pressure change among females (NDIT Study, 1999–2005)

From: The association between the angiotensin-converting enzyme-2 gene and blood pressure in a cohort study of adolescents

 

SBP, mmHg change

DBP, mmHg change

 

Beta (Confidence interval)1

Beta (Confidence interval)1

SNP2

French Canadian

European

Other

French Canadian

European

Other

rs2074192

−0.59 (−1.8, 0.6)

−1.54 (−0.6, -2.5)3

−1.48 (−3.2, 0.2)

−0.44 (−1.5, 0.6)

−0.20 (−1.0, 0.6)

−0.32 (−1.7, 1.0)

rs233575

0.30 (−1.3, 1.9)

1.95 (0.8, 3.1)4

1.41 (−0.6, 3.4)

0.87 (−0.3, 2.0)

0.67 (−0.1, 1.4)

−0.35 (−2.0, 1.3)

rs2158083

−0.05 (−1.4, 1.3)

1.20 (0.1, 2.3)5

2.83 (−0.2, 5.9)

0.39 (−0.7, 1.5)

0.53 (−0.2, 1.2)

0.06 (−2.3, 2.4)

rs1978124

0.34 (−1.0, 1.7)

0.78 (−0.3, 1.9)

0.04 (−1.4, 1.5)

−0.25 (−1.3, 0.8)

0.62 (−0.01, 1.2)

−0.45 (−1.6. 0.7)

  1. 1Adjusted for height, and whether or not the participant was overweight or obese; 2Reference groups were the major genotypes in accordance with dbSNP database: G for rs2074192 and rs1978124; T for rs233575 and rs2158083; 3 p-value=0.002; 4 p-value=0.002; 5 p-value=0.04.
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BMC Medical Genetics

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