Table 4 Distribution of the SOD2 gene Val16Ala polymorphism among groups, in albuminuria studies with T2D patients
Genotype TT/CT/CC | C allele frequency | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Macroalbuminuria | Normoalbuminuria | |||||||||
Authors (reference) | Year | Population | Number | P HW | Number | P HW | Cases | Controls | OR (95%CI) | P |
Nomiyama (15) | 2003 | Japan | 74/14/0 | 1.000 | 206/83/2 | 0.038 | 8.0 | 14.9 | 0.49 (0.27-0.89) | 0.017 |
Lee (16) | 2006 | Korean | 36/4/1 | 0.178 | 203/24/17 | <0.001 | 7.3 | 11.9 | 0.59 (0.24-1.40) | 0.225 |
Yang (17) | 2007 | Chinese | 47/15/11 | 1.000 | 23/25/2 | 0.183 | 25.3 | 29.0 | 0.83 (0.47-1.47) | 0.525 |
Liu (18) | 2009 | Chinese | 55/7/0 | 1.000 | 78/22/3 | 0.390 | 5.6 | 13.6 | 0.38 (0.16-0.90) | 0.023 |
Ascencio | 2013 | Mexican | 20/59/40 | 1.000 | 88/400/387 | 0.320 | 58.4 | 63.7 | 0.69 (0.52-0.91) | 0.008 |
All studies | 232/99/52 | <0.001 | 598/554/411 | <0.001 | 26.5 | 44.0 | 0.65 (0.52-0.80) | <0.001 | ||