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Table 5 Influence of the HU use in SCA patients with the Bantu/Benin haplotype

From: Genetic and biochemical markers of hydroxyurea therapeutic response in sickle cell anemia

Modulators

Bantu/Benin (+HU)

Bantu/Benin (−HU)

P values*

n = 06

n = 04

Hb F ( % )

17.41 ± 3.10

6.67 ± 4.37

0.0069#

TBARS (ng/mL)

1066.26 ± 495.09

1815.50 ± 334.80

0.0303#

TEAC (mM)

2.02 ± 0.16

2.08 ± 0.18

0.6124

GST (U/mL)

1.49 ± 0.62

1.27 ± 0.63

0.5925

CAT (U/mL)

2294.01 ± 297.29

1842.42 ± 397.81

0.0725

GSH (μM)

0.62 ± 0.37

0.84 ± 0.62

0.4981

  1. (−HU) patients not treated with HU. (+HU) patients treated with HU.
  2. *Comparisons were made by Mann–Whitney test.
  3. #Indicates statistical difference (p < 0.05).
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BMC Medical Genetics

ISSN: 1471-2350

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