Table 3 Descriptive analysis of the β S -haplotypes interference in the phenotypic expression of SCA patients
From: Genetic and biochemical markers of hydroxyurea therapeutic response in sickle cell anemia
Parameters | |||||||
|---|---|---|---|---|---|---|---|
Hb F (%) | TBARS (ng/mL) | TEAC (mM) | GST (U/mL) | CAT (U/mL) | GSH (μM) | ||
Haplotypes (+HU) | n | ||||||
Bantu/Bantu | 2 | 1.95 | 1201.18 | 2.17 | 1.26 | 1742.95 | 1.30 |
Bantu/Benin | 6* | 17.42 | 1066.26 | 2.03 | 1.50 | 2294.01 | 0.62 |
Benin/Benin | 1 | 5.2 | 1616.62 | 2.17 | 1.44 | 2278.17 | 1.10 |
Benin/Camer | 0 | ----- | ----- | ----- | ----- | ----- | ----- |
Bantu/Atp1 | 0 | ----- | ----- | ----- | ----- | ----- | ----- |
Benin/Atp1 | 1 | 1.8 | 1524.30 | 2.20 | 1.20 | 1531.69 | 0.19 |
Benin/Atp2 | 1 | 8.4 | 1012.00 | 2.01 | 2.00 | 1084.51 | 0.22 |
Benin/Atp3 | 1 | 7.3 | 1216.92 | 2.10 | 1.92 | 1880.28 | 0.88 |
Atp2/Atp2 | 1 | 11 | 1308.00 | 1.97 | 1.51 | 1866.20 | 0.37 |
Haplotypes (−HU) | |||||||
Bantu/Bantu | 6* | 6.78 | 2284.33 | 1.93 | 2.03 | 1656.10 | 0.77 |
Bantu/Benin | 4* | 6.68 | 1815.50 | 2.09 | 1.27 | 1842.43 | 0.84 |
Benin/Benin | 1 | 2.1 | 1222.00 | 2.09 | 1.65 | 2570.42 | 0.74 |
Benin/Camer | 1 | 4.8 | 934.00 | 1.90 | 2.00 | 996.48 | 0.70 |
Bantu/Atp1 | 1 | 3.2 | 1287.00 | 1.95 | 1.18 | 2017.61 | 0.87 |
Benin/Atp1 | 0 | ----- | ----- | ----- | ----- | ----- | ----- |
Benin/Atp2 | 0 | ----- | ----- | ----- | ----- | ----- | ----- |
Benin/Atp3 | 0 | ----- | ----- | ----- | ----- | ----- | ----- |
Atp2/Atp2 | 2 | 7.45 | 1576.00 | 1.77 | 1.45 | 1248.24 | 0.32 |