Skip to main content

Table 4 Association of key GWAS SNPs with asthma severity defined by BTS steps and atopy

From: Defining the contribution of SNPs identified in asthma GWAS to clinical variables in asthmatic children

SNP

Gene

Severity

Z

P

SPT

Z

P

  

Fam

Score

value

Fam

Score

value

rs2305480 C/T

GSDMB

272

-3.791

1.5×10 -4

220

-3.164

1.6×10-3

rs11078927 C/T

GSDMB

277

-3.701

2.2 ×10 -4

227

-3.133

1.7×10-3

rs1342326 T/G

IL33

180

+1.378

0.168

144

+2.585

9.7×10-3

rs3939286 G/A

IL33

204

+0.347

0.729

164

+2.146

0.032

rs3771166 C/T

IL18R1

269

-2.021

0.043

219

-1.683

0.092

rs1420101 G/A

IL1RL1

263

+1.577

0.115

218

+0.449

0.653

rs744910 A/G

SMAD3

268

+0.386

0.699

215

+0.157

0.875

rs2284033 A/G

IL2RB

268

+1.233

0.218

216

+1.265

0.206

rs1588265 A/G

PDE4D

235

-0.712

0.477

195

-0.360

0.719

rs2786098 C/A

CRB1

202

-1.021

0.307

158

-1.886

0.059

rs2244012 A/G

RAD50

188

+0.941

0.347

159

+1.242

0.214

  1. FBAT was used to test for association using the additive model [17]. SNP single nucleotide polymorphism, MAF minor allele frequency, Fam number of families in analysis (≥10 families). Severity = BTS classification (1–5) [18], SPT = positive skin prick test to one or more allergen. Bonferroni correction, P < 9.1×10-4 considered significant (bold).